Metforal 500 mg (Tablet)
Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults with type 2 diabetes
- Combination therapy with other oral antidiabetic agents or insulin
- Use in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose of 500 mg twice a day for adults
- Dose increases in increments of 500 mg or 850 mg
- Maximum daily dose up to 2550 mg for additional glycemic control
- Extended release tablet dosage regimen
- Renal impaired patient dosage considerations
Interaction
- No information available for Metforal and Furosemide interaction
- Nifedipine enhances absorption of Metforal
- Potential interaction with cationic drugs
- Minimal effects on Nifedipine by Metforal
- Drugs that produce hyperglycemia and impact glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure (GFR <30 mL/min)
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
- Acute or chronic diseases affecting renal or hepatic function
Side Effects
- Hemolytic anemia
- Lactic acidosis (very rare)
- Decreased vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance, encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes associated with increased risk during pregnancy
- Recommends insulin use during pregnancy
- Metformin excreted into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantially excreted by the kidney
- Increases risk of lactic acidosis with impaired renal function
- Lowers vitamin B12 level
- Increases risk of hypoglycemia when used with insulin
- Regular monitoring of renal function advised
- Metformin therapy recommendations before surgery
- Annual estimation of Vitamin B-12 levels for patients on continuous therapy
- Monitoring of blood glucose during combined therapy with sulphonylurea
Use in Special Populations
- Dosage adjustment based on renal function in elderly subjects
- No effect on growth and puberty detected during controlled clinical studies
- Particular caution recommended for children aged between 10 and 12 years
- Renal function assessment before treatment initiation and regularly thereafter
- Special caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen at doses up to 85 gm
- Lactic acidosis is a medical emergency
- Most effective method for removal of lactate and Metformin is hemodialysis
Therapeutic Class
Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children