Metforal 850 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Dosage & Administration
- Dosage should be individualized
- Comes in immediate release and extended release tablet forms
- Starting dose for adults and children
- Different dosing recommendations for renal-impaired patients
- Instructions for swallowing extended release tablet whole
Pharmacology
- Belongs to the biguanide class
- Lowers both basal and postprandial plasma glucose
- Mechanism of action different from sulfonylureas
- Improves insulin sensitivity and peripheral glucose uptake
Interaction
- Potential interaction with various drugs such as Cationic drugs, Nifedipine, Cimetidine, and others
- Certain drugs leading to hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Includes blood and lymphatic system disorders, metabolism and nutrition disorders, nervous system disorders, gastrointestinal disorders, hepatobiliary disorders, and skin and subcutaneous tissue disorders
Pregnancy & Lactation
- Associated with increased risk of congenital abnormalities and perinatal mortality if uncontrolled during pregnancy
- Excreted into human breast milk, limited data for breastfeeding
Precautions & Warnings
- Substantially excreted by the kidney, risk of accumulation and lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia in combination with insulin
- Regular monitoring of renal function advised
Use in Special Populations
- Dosage adjustment in elderly subjects based on renal function
- No effect on growth and puberty detected during controlled clinical studies
- Caution recommended for children aged between 10 and 12 years
Overdose Effects
- Hypoglycemia not seen at high doses, but lactic acidosis a possibility
- Lactic acidosis considered a medical emergency
- Hemodialysis as the most effective method to remove lactate and Metformin
Therapeutic Class
- Belongs to the therapeutic class of biguanides
Storage Conditions
- Requires storage below 30°C, protected from light and moisture
- Should be kept out of the reach of children