Tofix 200 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Team pharmaceuticals ltd |
Title
Tofix 200 mg Tablet
Categories
- Analgesic
- NSAID
- Migraine Relief
Description
Tofix 200 mg Tablet is a potent inhibitor of cyclooxygenase enzyme, used for relieving the pain of migraine headache, post-operative pain, and fever. It is absorbed from the GI tract, has a plasma half-life of 2 hours, and is metabolized in the liver. It interacts with Metoclopramide, Magnesium hydroxide, Aluminium hydroxide, anticoagulants, NSAIDs, loop diuretics, ACE Inhibitors, Lithium, Methotrexate, cardiac glycosides, ACE inhibitors, Ciclosporin, and Tacrolimus. This medicine is contraindicated in cases of active gastrointestinal bleeding, ulceration, severe heart failure, and during the third trimester of pregnancy. Side effects include alveolitis, hepatic damage, pancreatitis, Stevens-johnson syndrome, blood disorders, gastrointestinal bleeding, gastrointestinal discomfort, and visual disturbances. It should be stored in a cool and dry place away from light and children.
Dimensions
Not available
Color options
Not applicable
Functions
- Relieves migraine headache
- Analgesic for post-operative pain
- Fever reduction
Materials
Not applicable
Technical specifications
- Absorption: Readily absorbed from GI tract
- Peak plasma concentration: 60-90 min
- Bioavailability: 85%
- Protein binding: 99%
- Plasma half life: 2 hours
- Metabolism: Metabolised in the liver
- Excretion: Excreted in urine (90%) and feces
Design elements
Not applicable
Usability features
- Dosage adult:
- Acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
- Mild to moderate pain: 100-200 mg tid
- Renal impairment: Dose adjustments may be needed
- Severe renal impairment: Avoid
- Dosage children: A pediatric dosage regimen has not yet been established
- Administration: Take with food and water during or immediately after meals
- Interaction:
- Increases absorption with:
- Metoclopramide
- Magnesium hydroxide
- Decreases absorption with: Aluminium hydroxide
- Increases risk with:
- anticoagulants
- other NSAIDs
- Decreases response to:
- loop diuretics
- B-blockers
- ACE Inhibitors
- Increases plasma concentration of:
- Lithium
- Methotrexate
- cardiac glycosides
- Increases risk of: nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
- Increases absorption with:
- Contraindications:
- Active gastrointestinal bleeding
- Active gastrointestinal ulceration
- Severe heart failure
- History of gastrointestinal bleeding related to previous NSAID therapy
- History of gastrointestinal haemorrhage
- History of gastrointestinal perforation related to previous NSAID therapy
- History of recurrent gastrointestinal ulceration
- Side effects:
- Common:
- Gastrointestinal discomfort
- Nausea
- Dizziness
- Drowsiness
- Rare:
- Alveolitis
- Hepatic damage
- Pancreatitis
- Stevens-johnson syndrome
- Blood disorder
- Visual disturbances
- Common:
- Pregnancy lactation: Not recommended during pregnancy unless essential. Avoid in the third trimester. If possible, avoid when breastfeeding
- Precautions warnings:
- Asthma bronchospasm
- Bleeding disorders
- Cardiovascular diseases
- Peptic ulceration
- Hypertension
- Liver infection
- Cardiac or renal function impairment
- Elderly
- Increase water intake or dose reduction to reduce dysuria
- Overdose effects:
- Symptoms:
- Headache
- Nausea
- Vomiting
- Gastrointestinal bleeding
- Drowsiness
- Dizziness
- Convulsions
- Possible complications:
- Acute renal failure
- Liver damage
- Treatment: Symptomatic treatment as required
- Symptoms:
- Therapeutic class:
- Rheumatoid Arthritis drugs
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Migraine relief drugs
- Storage conditions: Store in a cool and dry place, away from light. Keep out of the reach of children