Nidipine SR 20 mg (Tablet (Sustained Release))
Unit Price: ৳ 0.64 (10 x 10: ৳ 64.00)
Strip Price: ৳ 6.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Nifedipine |
| Company | Square pharmaceuticals plc |
Indications
- Management of essential hypertension
- Management of renal hypertension
- Management of hypertension during pregnancy
- Management of hypertension during coronary bypass surgery
- Prophylaxis and treatment of unstable angina
- Prophylaxis and treatment of variant angina
- Treatment of myocardial infarction
- Treatment of silent myocardial ischaemia
- Treatment of Raynaud's phenomenon
- Treatment of heart failure
Pharmacology
- Inhibitor of Calcium Channel Blocker
- Selective dilator of arterial vessels
- Dilates main coronary and systemic arteries
- Reduces blood pressure and elicits sympathetic reflex response
- Negative inotropic effects on cardiac muscles
Dosage & Administration
- Starting dosage of Nifedipine 10 mg
- Starting dosage of Nifedipine 20 mg
- Dosage adjustment for elderly patients
- Dosage adjustment for patients with liver dysfunction
- Dosage adjustment for patients with renal impairment
- Angina dosage: 10 mg - 20 mg 3 times daily
- Raynaud's Phenomenon dosage: 10 mg 3 times daily
- Maximum dosage for Raynaud's Phenomenon: 60 mg daily
- Hypertension and angina prophylaxis dosage: 20 mg twice daily
- Dosage adjustment range: 10 mg twice daily to 40 mg twice daily
Interaction
- Enhanced hypotensive effect with ACE inhibitors
- Reduced plasma concentration of quinidine with anti-arrhythmics
- Possible increased metabolism with Rifampicin
- Increased plasma concentration of phenytoin with anti-epileptics
- Enhanced hypotensive effect with antipsychotics
- Severe hypotension and heart failure risk with β-blockers
- Possible increased plasma concentration with Cyclosporin
- Increased effect of muscle relaxants
- Increased metabolism with ulcer healing drugs
Contraindications
- Cardiogenic shock
- Advanced aortic stenosis
- Nursing mothers
- GI obstruction
- Inflammatory bowel disease
- Hypotension
Side Effects
- Headache
- Flushing
- Lethargy
- Gravitational oedema
- Rash
- Nausea
- Increased frequency of micturation
- Eye pain
- Gum hyperplasia
- Depression
- Tremor
- Photosensitivity
- Jaundice (rare)
Pregnancy & Lactation
- No adequate and well controlled studies in pregnant women
- Use during pregnancy only if the potential benefit justifies the potential risk to the fetus
Precautions & Warnings
- Tablets should be swallowed whole
- Caution in patients with poor cardiac reserve
- Use should be withdrawn if ischaemic pain occurs
- Control adjustment for diabetic patients
- Caution in treating patients with renal disease
Therapeutic Class
Calcium-channel blockers
Storage Conditions
Protect from strong light, store in a cool place in the original pack