Napgin Plus 500 mg+20 mg (Tablet (Delayed Release))
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
Category | Details |
---|---|
Generic | Naproxen sodium esomeprazole magnesium |
Company | Biopharma limited |
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Decreasing risk of developing gastric ulcers
Pharmacology
- Immediate release Esomeprazole Magnesium layer
- Enteric-coated Naproxen core
- Inhibition of prostaglandin synthesis
- Proton pump inhibitor suppressing gastric acid secretion
Dosage
- Lowest effective dose
- Twice daily dosage for different conditions
- Dosage for juvenile idiopathic arthritis based on weight
Administration
- Tablet to be taken at least 30 minutes before meals
Interaction
- Concomitant use of NSAIDs reducing antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
- Increased risk of bleeding complication with warfarin
- Inhibition of gastric acid secretion interfering with drug absorption
- Effects of administration with high-fat food on absorption
Contraindications
- Known hypersensitivity to components
- History of allergic-type reactions after taking aspirin or other NSAIDs
- Use during peri-operative period in the setting of coronary artery bypass graft surgery
Side Effects
- Decrease in occurrence of gastric ulcers and NSAID associated adverse events
- Increased risk of arterial thrombotic events at high doses
- Gastrointestinal adverse events
- Oedema, hypertension, cardiac failure
- Nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, gastrointestinal bleeding, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease
Pregnancy & Lactation
- Contradiction during third trimester of pregnancy
- Unknown excretion of esomeprazole in human milk
- Impairment of female fertility
- Not recommended for women attempting to conceive
Precautions & Warnings
- Avoiding combination with other NSAIDs
- Usage with low dose acetylsalicylic acid
- Risk-factors for NSAID related gastro-intestinal complications
- Increased frequency of adverse reactions in older people
- Consideration for patients with GI toxicity
- Monitoring and advice required for patients with history of hypertension and/or mild to moderate congestive heart failure
Use in Special Populations
- Increased unbound plasma fraction of naproxen in elderly
- Not recommended usage in patients with moderate to severe or severe renal impairment
- Close monitoring for patients with mild to moderate hepatic impairment
Overdose Effects
- Symptoms of Naproxen overdose
- Symptoms of esomeprazole overdose
- Management of overdose through symptomatic and supportive care
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store at temperature below 30°C
- Protect from light & moisture
- Keep out of reach of children
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