Pepto 87.5 mg/5 ml (Oral Suspension)

Indications

• upset stomach
• indigestion
• heartburn
• nausea
• diarrhea

Pharmacology

• Bismuth Subsalicylate coats ulcer surface
• stimulates mucus and bicarbonate secretion
• reacts with HCl
• produces bismuth oxychloride and salicylic acid
• stimulates absorption of water and electrolytes
• binds with toxin produced by E.coli
• disrupts cell causing lysis of H.pylori
• prevents adhesion of H.pylori in the cell wall of intestine
• inhibits prostaglandin G/H synthase
• retards the expulsion of fluid

Dosage & Administration

• Adult (>16): 30 ml in dosing cup provided or 6x5 ml spoonful
• Children (10-14 years): 15 ml (3 teaspoons)
• Children (5-9 years): 7.5 ml (1.5 teaspoons)
• Children (3-4 years): 5 ml (1 teaspoon)
• Children under 3 years: Ask a doctor
• Repeat dose every 1/2 to 1 hour if needed
• Not more than 8 doses to be taken in 24 hours

Interaction

• Contains salicylates
• care should be exercised if receiving anticoagulant therapy
• care should be exercised if receiving oral therapy for diabetes
• care should be exercised if receiving treatment for gout or arthritis

Contraindications

• Should not be used by patients hypersensitive to Aspirin or other salicylates
• Should not be used if symptoms are severe or persist for more than 2 days

Side Effects

• Black stool and black tongue
• should not be used if symptoms are severe or persist for more than 2 days

Pregnancy & Lactation

• No adequate data concerning the use of Bismuth Subsalicylate in pregnant women
• Bismuth Subsalicylate should not be used during lactation unless clearly necessary

Precautions & Warnings

• Do not take with aspirin or other salicylates
• Caution should be exercised by patients taking medicines for anti-coagulation, diabetes, or gout

Overdose Effects

• Acute encephalopathy with confusion
• myoclonic movements
• tremor
• gastrointestinal disturbances
• skin reactions
• discoloration of mucous membranes
• renal dysfunction
• tinnitus
• sweating
• nausea
• headache

Storage Conditions

• Keep below 30°C temperature
• away from light & moisture
• Keep out of the reach of children

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