Angimil 80 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Verapamil hydrochloride |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Title
- Angimil Tablet
- Angimil Injection
Categories
- Medicine
- Therapeutic Class: Calcium-channel blockers
Description
Angimil is a calcium ion influx inhibitor that inhibits the inward movement of calcium into cardiomyocytes, smooth muscle cells and His-Purkingi system. The tablets are designed for sustained release of the drug in the intestine.
Indications
- Essential hypertension
- Angina pectoris and prevention of re-infarction
- Supraventricular arrhythmias
- Tachycardias such as: Paroxysmal supraventricular tachycardias
- Atrial fibrillation with rapid ventricular response
- Atrial flutter with rapid conduction
- Extrasystoles
- Acute hypertension
- Acute coronary insufficiency
- Prophylaxis and/or therapy of ectopic arrhythmias in halothane anesthesia
Pharmacology
Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity. Immediate-release verapamil has a relatively short duration of action, requiring dosing 3 to 4 times daily, but extended-release formulations are available that allow for once-daily dosing.
Dosage and Administration
- Verapamil Tablet: Individualized titration with food, essential hypertension initial dose 180 mg in the morning, angina usual dose 80-120 mg three times a day, arrhythmias dosing in digitalized patients
- Verapamil Injection: Dosing for adults and children by age and action, slow intravenous injection, dosing in hypertensive crises, average total dose up to 1.5 mg/kg/day
Interaction
- May increase plasma level with CYP3A4 inhibitors
- May decrease plasma level with CYP3A4 inducers
- Increased risk of bleeding with aspirin
- May increase bradycardic and hypotensive effect with telithromycin
- Increased AV blocking effect with clonidine
- May increase plasma level of various medications
- May potentiate hypotensive effect with diuretics, antihypertensives, vasodilators
- May increase neurotoxic effect of lithium
Contraindications
- Severe left ventricular dysfunction
- Hypotension or cardiogenic shock
- Sick sinus syndrome
- Second or third-degree atrioventricular (AV) block
- Patients with certain types of atrial flutter or atrial fibrillation
- Known hypersensitivity to verapamil hydrochloride
Side Effects
- Digestive system: Constipation, nausea
- Cardiovascular system: Hypotension, edema, CHF, pulmonary edema, bradycardia, AV block
- Respiratory system: Upper respiratory tract infections
- Nervous system: Dizziness, headache, fatigue
- Skin: Rash, flashing
- Hepatic: Elevated liver enzyme
Pregnancy and Lactation
No adequate and well-controlled studies in pregnant women, excreted in breast milk.
Precautions and Warnings
- Taken with caution in specific conditions
- May impair ability to drive or operate machinery
- Slows down elimination of alcohol and prolongs effects of alcohol
Overdose Effects
Treatment should be supportive, use of beta-adrenergic stimulation or parenteral administration of calcium solution
Storage Conditions
Do not store above 30°C, keep away from light, and out of the reach of children