Wellmet 850 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company One pharma ltd
Also available as
Wellmet 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of overweight patients with inadequate glycaemic control

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Different dosages for adults and children
  • Different dosages for immediate release and extended release tablets
  • Special dosage considerations for renal impaired patients

Interaction

  • No information available about Wellmet and Furosemide interaction
  • Nifedipine may enhance Wellmet absorption
  • Potential interaction with cationic drugs through renal tubular transport systems
  • Effects of Wellmet on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia and impact glycemic control

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions that can alter renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Gastrointestinal disorders
  • Hepatic function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Excretion of metformin into human breast milk
  • Recommendation against breastfeeding during metformin treatment

Precautions & Warnings

  • Substantial excretion of Wellmet by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Discontinuation of Wellmet before surgery and certain clinical investigations
  • Annual estimation of Vitamin B-12 levels
  • Interaction considerations with other drugs

Use in Special Populations

  • Adjustment of metformin dosage based on renal function in elderly subjects
  • Confirmation of type 2 diabetes mellitus diagnosis before metformin initiation in pediatric population
  • Caution in prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function
  • Special caution in situations where renal function may become impaired

Overdose Effects

  • No hypoglycemia seen with doses up to 85 gm
  • Occurrence of lactic acidosis in overdose situations
  • Treatment of lactic acidosis as a medical emergency

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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