Wellmet 500 mg (Tablet)

Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company One pharma ltd
Also available as
Wellmet 850 mg tablet

Therapeutic Class

  • Biguanides

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy in adults
  • Combination therapy in adults
  • Combination therapy in children and adolescents

Pharmacology

  • Lowers basal and postprandial plasma glucose
  • Different mechanism from sulfonylureas
  • No hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity
  • Increases peripheral glucose uptake

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Usual starting dose for adults and children
  • Dosage increases in increments
  • Metformin immediate release tablet usage
  • Metformin extended release tablet usage
  • Renal impaired patient precautions

Interaction

  • Co-administration with Furosemide
  • Enhancement of Nifedipine absorption
  • Effect on cationic drugs
  • Effect on Cimetidine pharmacokinetics
  • Drugs causing hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes risk during pregnancy
  • Use of insulin during pregnancy
  • Excretion into human breast milk
  • Adverse effects on breastfed newborns/infants

Precautions & Warnings

  • Risk of lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Excretion by the kidney
  • Monitoring of renal function
  • Adjustment during surgery and clinical investigations

Use in Special Populations

  • Adjustment for decreased renal function in elderly subjects
  • Effect on growth and puberty
  • Effects on prepubescent children
  • Renal function assessment
  • Caution in children aged between 10 and 12 years

Overdose Effects

  • Hypoglycemia
  • Lactic acidosis
  • Emergency treatment in hospital
  • Hemodialysis for removal

Storage Conditions

  • Temperature below 30°C
  • Protection from light & moisture
  • Keep out of the reach of children

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