Voritec 50 mg (Tablet)

Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00

Medicine Details

Category Details
Generic Voriconazole
Company Ziska pharmaceuticals ltd
Also available as

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia (nonneutropenic)
  • Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani
  • Use in patients intolerant of, or refractory to other therapy

Pharmacology

  • Triazole antifungal medication
  • Binds and inhibits ergosterol synthesis
  • Inhibits CYP450-dependent 14-alpha sterol demethylase
  • Results in depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Oral administration
  • Tablet and powder for suspension
  • To be taken at least one hour before or one hour following a meal
  • Loading and maintenance dose regimen based on body weight
  • Injection for specific fungal infections

Interaction

  • Adjust dosage with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
  • Potential increase in drug concentrations and activity with CYP3A4, CYP2C9 and CYP2C19 substrates
  • Increased dosage with co-administration of specific drugs

Contraindications

  • Known hypersensitivity to Voriconazole or any other components
  • Co-administration with specific drugs leading to serious adverse reactions or loss of efficacy

Side Effects

  • Abdominal pain
  • Anemia
  • Blurred vision
  • Headache
  • Chest pain
  • Nausea
  • Diarrhea

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Careful assessment of benefit-risk balance for long term exposure
  • Reports of squamous cell carcinoma of the skin (SCC) with long-term treatment

Use in Special Populations

  • Efficacy not established for children under 12 years of age

Overdose Effects

  • No data available

Therapeutic Class

  • Other antifungal preparations

Reconstitution

  • Shake the bottle well before reconstitution
  • Add specified amount of boiled and cooled water to the bottle
  • Shake vigorously until powder is completely mixed with water
  • Store reconstituted suspension between specific temperatures
  • Discard suspension after specified duration

Storage Conditions

  • Keep out of reach of children
  • Store in specific dry place and temperature
  • Store Voritec powder for suspension between specific temperature range

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