Voritec 50 mg (Tablet)
Unit Price: ৳ 50.00 (1 x 10: ৳ 500.00)
Strip Price: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia (nonneutropenic)
- Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani
- Use in patients intolerant of, or refractory to other therapy
Pharmacology
- Triazole antifungal medication
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral administration
- Tablet and powder for suspension
- To be taken at least one hour before or one hour following a meal
- Loading and maintenance dose regimen based on body weight
- Injection for specific fungal infections
Interaction
- Adjust dosage with CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers
- Potential increase in drug concentrations and activity with CYP3A4, CYP2C9 and CYP2C19 substrates
- Increased dosage with co-administration of specific drugs
Contraindications
- Known hypersensitivity to Voriconazole or any other components
- Co-administration with specific drugs leading to serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
- Careful assessment of benefit-risk balance for long term exposure
- Reports of squamous cell carcinoma of the skin (SCC) with long-term treatment
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No data available
Therapeutic Class
- Other antifungal preparations
Reconstitution
- Shake the bottle well before reconstitution
- Add specified amount of boiled and cooled water to the bottle
- Shake vigorously until powder is completely mixed with water
- Store reconstituted suspension between specific temperatures
- Discard suspension after specified duration
Storage Conditions
- Keep out of reach of children
- Store in specific dry place and temperature
- Store Voritec powder for suspension between specific temperature range