Varox 10 mg (Tablet)
Unit Price: ৳ 25.00 (1 x 14: ৳ 350.00)
Strip Price: ৳ 350.00
Medicine Details
Category | Details |
---|---|
Generic | Rivaroxaban |
Company | Drug international ltd |
Also available as |
Indications
- Prevention of atherothrombotic events after Acute Coronary Syndrome
- Reduction of stroke and systemic embolism in nonvalvular atrial fibrillation
- Treatment and prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)
- Prophylaxis of DVT in patients undergoing knee or hip replacement surgery
Pharmacology
- Highly selective direct factor Xa inhibitor
- Interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade
- Does not inhibit thrombin
- No effects on platelets
Dosage & Administration
- Recommended dosage for different conditions
- Variety of dosing options based on patient's condition and creatinine clearance
- May be taken with or without food
Interaction
- Concomitant use with drugs affecting P-gp and CYP3A4 inhibitors
- Contraindicated with strong CYP3A4 inducers
- Increased risk of bleeding with concomitant use of certain drugs
Contraindications
- Known hypersensitivity to Rivaroxaban or its excipients
- Active pathological bleeding
Side Effects
- Increased chance of bleeding
- Spinal or epidural hematoma
- Increased risk of stroke after discontinuation in nonvalvular atrial fibrillation
Pregnancy & Lactation
- Pregnancy category C drug
- No established dosing for pregnant women
- Unknown excretion in human milk
- Safety and efficacy not established in breastfeeding women
Precautions & Warnings
- Increased risk of thrombotic events with early discontinuation
- Risk of fatal bleeding in the presence of certain risk factors
- Monitoring of neurological impairment in cases of neuraxial anesthesia
- Not recommended in certain patient populations
Overdose Effects
- May lead to hemorrhage
- Limited systemic exposure at single doses >50 mg
- No specific antidote available
Therapeutic Class
- Oral Anti-coagulants
Storage Conditions
- Store below 30°C, protected from light