Epomax 3000 IU (IV/SC Injection)

3000 IU pre-filled syringe: ৳ 700.00

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Drug international ltd
Also available as
Epomax 5000 iu injection

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis and not on dialysis
  • Treatment of anemia due to Zidovudine in HIV-infected patients
  • Treatment of anemia due to concomitant myelosuppressive chemotherapy
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with specified birth weight and gestational age

Description

  • Recombinant human erythropoietin (EPO)
  • Expressed in Chinese hamster ovary cells
  • Has a 165 amino acid sequence identical to that of human urinary EPO
  • Apparent molecular weight of erythropoietin is about 30,400 daltons

Dosage

  • Evaluation of Iron Stores and Nutritional Factors before and during treatment
  • Monitoring hemoglobin levels at least weekly until stable, then at least monthly
  • Adjusting therapy based on hemoglobin rate of rise, ESA responsiveness, and hemoglobin variability
  • Initiating Erythropoietin alfa treatment based on hemoglobin levels
  • Dose adjustments for patients with CKD on dialysis and not on dialysis
  • Starting dose for Zidovudine-treated HIV-infected Patients
  • Dosing adjustments and discontinuation criteria for patients on Cancer Chemotherapy
  • Dosing regimen for prevention of anemia of prematurity

Administration

  • Important preparation and administration instructions
  • Need to inspect visually for particulate matter and discoloration before administration
  • Recommendation to protect syringe from light
  • Disposal instructions for unused portions

Interaction

  • Potential potentiation of Epomax effect by simultaneous administration of a haematinic agent

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Patients developing Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions observed in Epomax treated patients in clinical studies
  • Specific adverse reactions for patients with CKD, Zidovudine-treated HIV-infected Patients, Cancer Patients on Chemotherapy, Surgery Patients, and Premature infants

Pregnancy & Lactation

  • Absence of adequate and well-controlled studies in pregnant women
  • Reproduction toxicology observed in animal studies
  • Caution advised in pregnancy and lactation
  • Unknown excretion of exogenous Erythropoietin alfa in human milk

Overdose Effects

  • Wide therapeutic margin of Epomax
  • Management of hemoglobin levels above the desired level in case of overdosage
  • Cases of severe hypertension observed following overdose with ESAs

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

  • Recommended storage temperature range
  • Instructions to avoid freezing or shaking
  • Necessity to protect from light by storing in original package

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