Rivatig 1.5 mg (Capsule)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivastigmine tartrate |
| Company | Square pharmaceuticals plc |
Indications
- Symptomatic treatment of mild to moderately severe Alzheimer's dementia
- Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease
Pharmacology
- Carbamate derivative related to physostigmine
- Binds reversibly with and inactivates cholinesterase
- Increases concentration of acetylcholine at cholinergic synapses
- Relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues
Dosage
- Rivastigmine capsule initial dose: 1.5 mg twice a day
- Dose titration: 1.5 mg to 6 mg twice a day
- Rivastigmine transdermal patch initial dose: 4.6 mg/24 hours
- Dose titration: 4.6 mg to 13.3 mg/24 hours
Administration
Twice a day, with morning and evening meals
Interactions
- Exaggerates effects of succinylcholine-type muscle relaxants
- Should not be given concomitantly with other cholinomimetic substances
- No pharmacokinetic interaction observed with digoxin, warfarin, diazepam, or fluoxetine
Contraindications
Contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives
Side Effects
- Gastrointestinal adverse reactions
- Nausea (38%) and vomiting (23%)
- Female patients more susceptible than male patients to gastrointestinal adverse reactions and weight loss
Pregnancy & Lactation
- Not recommended during pregnancy unless clearly necessary
- Excreted into milk, should not be used while breastfeeding
Precautions & Warnings
- Caution in patients with sick sinus syndrome or conduction defects
- May exacerbate urinary obstruction and seizures
- Monitor body weight
- May worsen extrapyramidal symptoms
Use in Special Populations
- Increased exposure in moderate renal and mild to moderate hepatic impairment
- Not recommended for use in children
Overdose Effects
- Most cases of accidental overdose not associated with clinical signs or symptoms
- Symptoms may include nausea, vomiting, diarrhea, hypertension, hallucinations
- Bradycardia and/or syncope may also occur
Therapeutic Class
Drugs for Dementia
Storage Conditions
Store in a cool and dry place, protected from light