Carbizol 10 mg (Tablet)

Indications

• Management of hyperthyroidism
• Treatment of thyrotoxicosis
• Preparation of patients for thyroidectomy
• Combination therapy with radio-active ablative therapy

Pharmacology

• Depresses the formation of thyroid hormone
• Reduces uptake and concentration of inorganic iodine by the thyroid
• Reduces formation of di-iodotyrosine and thyroxine
• Rapid absorption from the gastro-intestinal tract
• Complete metabolism to methimazole
• Crosses placental barrier and high concentration in lactating patient's milk

Dosage & Administration

• Initial dose: 20-60 mg in 2-3 divided doses until euthyroid
• Maintenance dose: gradually reduced to maintain euthyroid state (5-15 mg/day)
• Initial dose for neonates & children below 12 years: 250 mcg/kg/day in divided doses
• Duration of treatment: 18 to 24 months

Interaction

• Decreased response to Carbizol with iodine or iodine excess
• Possible need for increased dosage or longer duration with antithyroid agents
• Effect on response to oral anticoagulants
• Enhanced anticoagulant effects with thioamide-induced hypoprothrombinemia
• Possible increase in serum concentrations of digoxin and digitoxin

Contraindications

• Hypersensitivity to carbimazole or other thiourea antithyroid agents

Side Effects

• Rash
• Pruritis
• Skin pigmentation
• Paraesthesias
• Urticaria
• Headache
• Arthralgia
• Gastro-intestinal disturbances (nausea, vomiting, gastric discomfort)
• Abnormal hair loss
• Drug fever
• Lupus-like syndrome
• Vasculitis
• Nephritis
• Hepatic disorders (jaundice)
• Taste disturbances

Pregnancy & Lactation

• Use in pregnancy with smallest effective dose
• Potential adverse effects on the fetus
• Potential to cause foetal or neonatal hypothyroidism and goitre

Precautions & Warnings

• Caution with tracheal obstruction
• High dosages may produce thyroid enlargement

Overdose Effects

• Hypothyroidism
• Goitre
• Potential blood dyscrasias
• Immediate withdrawal if blood dyscrasias occur
• Symptomatic and supportive treatment

Therapeutic Class

• Anti-thyroid drugs

Storage Conditions

• Storage temperature below 30°C
• Protect from light and moisture
• Keep out of reach of children

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