Veracal 5 mg/2 ml (IV Infusion)
2 ml ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Verapamil hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Product Title
- Veracal Tablet
- Veracal Injection
Categories
- Antihypertensive
- Antiarrhythmic
- Anti-anginal
- Calcium Channel Blocker
- Pharmacology
Dosage Form
- Tablet
- Injection
Color Options
- Not Applicable
Indications
- Essential hypertension
- Angina pectoris and prevention of re-infarction
- Supraventricular arrhythmias
- Tachycardias
- Atrial fibrillation with rapid ventricular response
- Atrial flutter with rapid conduction
- Extrasystoles
- Acute hypertension
- Acute coronary insufficiency
- Prophylaxis and/or therapy of ectopic arrhythmias
- Halothane anaesthesia
- Application of adrenaline in halothane anaesthesia
Pharmacological Action
- Calcium ion influx inhibitor
- Inhibits inward movement of calcium into cardiomyocytes
- Inhibits inward movement of calcium into smooth muscle cells
- Inhibits inward movement of calcium into His-Purkingi system
- L-type calcium channel blocker
- Antiarrhythmic activity
- Antianginal activity
- Antihypertensive activity
- Negative inotropic medication
Dosage & Administration
- Individualized dosing by titration
- Administered with food
- Sustained release for intestinal drug delivery
- Varying doses for hypertension, angina, and arrhythmias
- Intravenous administration in tachycardias and hypertensive crises
- Slow intravenous injection for children
- Intravenous infusion in hypertensive crises
Interactions
- Plasma level increase with CYP3A4 inhibitors
- Plasma level decrease with CYP3A4 inducers
- Increased risk of bleeding with aspirin
- Potentiation of other medication effects
- Potentiation of hypotensive effect with diuretics, antihypertensives, vasodilators
- Potentiation of neurotoxic effect of lithium
Contraindications
- Severe left ventricular dysfunction
- Hypotension or cardiogenic shock
- Sick sinus syndrome
- Second or third-degree atrioventricular (AV) block
- Patients with atrial flutter or atrial fibrillation and an accessory by pass tract
- Known hypersensitivity to verapamil hydrochloride
Side Effects
- Constipation
- Nausea
- Hypotension
- Edema
- Congestive heart failure (CHF)
- Pulmonary edema
- Bradycardia
- Atrioventricular (AV) block
- Upper respiratory tract infections
- Dizziness
- Headache
- Fatigue
- Rash
- Flashing
- Elevated liver enzymes
Pregnancy & Lactation
- Crosses placental barrier
- Excreted in breast milk
- Discontinue nursing while administered
Precautions & Warnings
- 1st degree AV block
- Bradycardia <50 beats/minute
- Hypotension <90 mm Hg systolic pressure
- Atrial fibrillation/flutter
- Simultaneous pre-excitation syndrome eg. WPW syndrome
- Care when driving or operating machinery
- Prolongs effects of alcohol
Overdose Effects
- Supportive treatment
- Possible use of beta-adrenergic stimulation
- Possible use of parenteral administration of calcium solution
- Hemodialysis ineffective for removal
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children