Prazolok ER 2.5 mg (Tablet (Extended Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Prazosin hydrochloride
Company Square pharmaceuticals plc
Also available as
Prazolok 1 mg tablet Prazolok 2 mg tablet Prazolok er 5 mg tablet

Indications

  • Hypertension
  • Primary hypertension
  • Secondary hypertension
  • Left ventricular failure
  • Raynaud's phenomenon
  • Raynaud's disease
  • Benign prostatic hyperplasia

Pharmacology

  • Decrease in total peripheral vascular resistance
  • Inhibition of postsynaptic alpha-1-adrenoreceptors
  • Therapeutic efficacy in congestive heart failure
  • Reduction in left ventricular filling pressure
  • Reduction in cardiac impedance
  • Augmentation of cardiac output
  • Antagonism of alpha-1-receptors on prostatic and urethral smooth muscle
  • Improvement of urinary pressure profile
  • No adverse changes in the serum lipid profile

Dosage & Administration

  • Titration of dosage based on patient's response
  • Therapy initiation with low starting dose
  • Twice or three times daily regimen
  • Recommended starting dose for left ventricular failure
  • Recommended starting dosage for Raynaud's phenomenon and Raynaud's disease
  • Recommended starting dose for benign prostatic hyperplasia
  • Extended-release tablet for hypertension therapy
  • Maintenance dose adjustment
  • Switching from Prazosin Tablets to Prazosin XR Extended Release Tablets
  • Additive hypotensive effect with diuretic or other antihypertensive agent

Interaction

  • No adverse drug interaction observed with cardiac-glycosides
  • No adverse drug interaction observed with hypoglycemic agents
  • No adverse drug interaction observed with tranquilizers and sedatives
  • No adverse drug interaction observed with antiarrhythmic agents
  • No adverse drug interaction observed with analgesic, antipyretic and anti-inflammatory agents

Contraindications

  • Contraindicated in patients with known sensitivity to quinazolines

Side Effects

  • Dizziness
  • Headache
  • Drowsiness
  • Lack of energy
  • Weakness
  • Palpitations
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal discomfort
  • Liver function abnormalities
  • Pancreatitis
  • Edema
  • Orthostatic hypotension
  • Dyspnea
  • Faintness
  • Tachycardia
  • Nervousness
  • Vertigo
  • Hallucinations
  • Depression
  • Rash
  • Pruritus
  • Alopecia
  • Lichen planus
  • Urinary frequency
  • Impotence
  • Incontinence
  • Priapism
  • Blurred vision
  • Reddened solera
  • Epistaxis
  • Tinnitus
  • Dry mouth
  • Nasal congestion
  • Diaphoresis
  • Fever
  • Positive ANA liter
  • Arthralgia

Pregnancy & Lactation

  • No teratogenic effects seen in animal testing
  • Prazosin use during pregnancy not fully established
  • Use during pregnancy only if potential benefit justifies potential risk
  • Excreted in small amounts in human milk
  • Caution when administered to nursing mothers

Precautions & Warnings

  • Postural hypotension
  • Caution in patients with left ventricular failure
  • Monitoring of blood pressure during initial administration and titration for Raynaud's phenomenon and Raynaud's disease
  • Monitoring of blood pressure for patients with benign prostatic hyperplasia

Use in Special Populations

  • Not recommended for children under 12 years
  • Not recommended for left ventricular failure due to mechanical obstruction
  • Efficacy not established for left ventricular failure due to recent myocardial infarction

Overdose Effects

  • Profound drowsiness and depressed reflexes observed in pediatric overdose
  • Support of cardiovascular system of first importance in case of hypotension
  • Monitoring and support of renal function as needed
  • Not dialyzable because it is protein bound

Therapeutic Class

  • Alpha adrenoceptor blocking drugs

Storage Conditions

  • Keep away from light and moisture
  • Store below 30°C
  • Keep away from reach of children

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