Prazolok ER 2.5 mg (Tablet (Extended Release))
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prazosin hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Hypertension
- Primary hypertension
- Secondary hypertension
- Left ventricular failure
- Raynaud's phenomenon
- Raynaud's disease
- Benign prostatic hyperplasia
Pharmacology
- Decrease in total peripheral vascular resistance
- Inhibition of postsynaptic alpha-1-adrenoreceptors
- Therapeutic efficacy in congestive heart failure
- Reduction in left ventricular filling pressure
- Reduction in cardiac impedance
- Augmentation of cardiac output
- Antagonism of alpha-1-receptors on prostatic and urethral smooth muscle
- Improvement of urinary pressure profile
- No adverse changes in the serum lipid profile
Dosage & Administration
- Titration of dosage based on patient's response
- Therapy initiation with low starting dose
- Twice or three times daily regimen
- Recommended starting dose for left ventricular failure
- Recommended starting dosage for Raynaud's phenomenon and Raynaud's disease
- Recommended starting dose for benign prostatic hyperplasia
- Extended-release tablet for hypertension therapy
- Maintenance dose adjustment
- Switching from Prazosin Tablets to Prazosin XR Extended Release Tablets
- Additive hypotensive effect with diuretic or other antihypertensive agent
Interaction
- No adverse drug interaction observed with cardiac-glycosides
- No adverse drug interaction observed with hypoglycemic agents
- No adverse drug interaction observed with tranquilizers and sedatives
- No adverse drug interaction observed with antiarrhythmic agents
- No adverse drug interaction observed with analgesic, antipyretic and anti-inflammatory agents
Contraindications
- Contraindicated in patients with known sensitivity to quinazolines
Side Effects
- Dizziness
- Headache
- Drowsiness
- Lack of energy
- Weakness
- Palpitations
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort
- Liver function abnormalities
- Pancreatitis
- Edema
- Orthostatic hypotension
- Dyspnea
- Faintness
- Tachycardia
- Nervousness
- Vertigo
- Hallucinations
- Depression
- Rash
- Pruritus
- Alopecia
- Lichen planus
- Urinary frequency
- Impotence
- Incontinence
- Priapism
- Blurred vision
- Reddened solera
- Epistaxis
- Tinnitus
- Dry mouth
- Nasal congestion
- Diaphoresis
- Fever
- Positive ANA liter
- Arthralgia
Pregnancy & Lactation
- No teratogenic effects seen in animal testing
- Prazosin use during pregnancy not fully established
- Use during pregnancy only if potential benefit justifies potential risk
- Excreted in small amounts in human milk
- Caution when administered to nursing mothers
Precautions & Warnings
- Postural hypotension
- Caution in patients with left ventricular failure
- Monitoring of blood pressure during initial administration and titration for Raynaud's phenomenon and Raynaud's disease
- Monitoring of blood pressure for patients with benign prostatic hyperplasia
Use in Special Populations
- Not recommended for children under 12 years
- Not recommended for left ventricular failure due to mechanical obstruction
- Efficacy not established for left ventricular failure due to recent myocardial infarction
Overdose Effects
- Profound drowsiness and depressed reflexes observed in pediatric overdose
- Support of cardiovascular system of first importance in case of hypotension
- Monitoring and support of renal function as needed
- Not dialyzable because it is protein bound
Therapeutic Class
- Alpha adrenoceptor blocking drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C
- Keep away from reach of children