Tazocilin (2 gm+0.25 gm)/vial (IV Infusion)

2.25 gm vial: ৳ 550.00

Medicine Details

Category Details
Generic Piperacillin tazobactam
Company Square pharmaceuticals plc
Also available as
Tazocilin 4 gm injection

Title

  • Piperacillin and Tazobactam Injection

Categories

  • Antibiotic
  • Intravenous Solution
  • Pharmacological Drug
  • Therapeutic Medication

Indications

  • Treatment of moderate to severe intra-abdominal infections
  • Treatment of skin and skin structure infections
  • Treatment of female pelvic infections
  • Treatment of community-acquired pneumonia
  • Treatment of nosocomial pneumonia
  • Effective against susceptible isolates of designated bacteria

Pharmacology

  • Broad spectrum penicillin
  • Bactericidal activity against gram-positive and gram-negative bacteria
  • Inhibition of septum and cell wall synthesis
  • Potent inhibitor of beta-lactamases

Dosage & Administration

  • To be administered by intravenous infusion over 30 minutes
  • Adult dose: 3.375g every six hours
  • Pediatric dosage based on age and body weight
  • Duration of treatment: 7 to 14 days depending on the condition

Interactions

  • Potential interactions with aminoglycosides, probenecid, anticoagulants, vecuronium, and methotrexate

Contraindications

  • Allergic reactions to penicillins, cephalosporins, or beta-lactamase inhibitors

Side Effects

  • Adverse events involving the skin, gastrointestinal system, immune system, infections, metabolism, musculoskeletal system, psychiatric disorders, vascular system, and respiratory system
  • Range of reported side effects including rash, pruritus, diarrhea, constipation, nausea, vomiting, hypersensitivity reactions, hypoglycemia, myalgia, and epistaxis

Pregnancy & Lactation

  • Crosses the placenta in humans
  • Insufficient data for safety in pregnant women
  • Excreted in human milk

Precautions & Warnings

  • Reported instances of serious hypersensitivity reactions, severe cutaneous adverse reactions, and hematological effects
  • Nephrotoxicity observed in critically ill patients
  • Clostridium difficile associated diarrhea to be evaluated if it occurs

Use in Special Populations

  • Supported use in pediatric patients 2 months of age and older
  • Dosage adjustment for patients with renal impairment
  • No dosage adjustment warranted in patients with hepatic cirrhosis
  • Increased incidence of fever and rash in cystic fibrosis patients

Overdose Effects

  • Reported overdose effects including nausea, vomiting, diarrhea, neuromuscular excitability, and convulsions
  • Supportive and symptomatic treatment recommended

Therapeutic Class

  • Broad spectrum penicillins
  • Other beta-lactam antibiotics

Reconstitution

  • Preparation of solution for intravenous infusion using 0.9% Sodium Chloride solution
  • Detailed instructions for reconstitution and administration
  • Storage guidelines for reconstituted solution

Storage Conditions

  • Storage temperature below 30°C
  • Protection from light and moisture
  • Keep out of reach of children

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