Limpet M 2 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 12.00 (3 x 7: ৳ 252.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Drug international ltd
Also available as
Limpet m 1 mg tablet

Indications

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • For patients who do not achieve adequate glycemic control with glimepiride or metformin monotherapy
  • As a replacement for combination therapy of glimepiride and metformin

Pharmacology

  • Decreases blood glucose concentration
  • Stimulates insulin release from pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin and glucose uptake

Dosage

  • Governed by desired blood glucose levels
  • Must be the lowest sufficient to achieve desired metabolic control
  • Glucose levels in blood and urine must be measured regularly
  • Highest recommended dose per day: 8 mg of glimepiride and 2000 mg of metformin
  • Starting dose should not exceed daily doses of glimepiride or metformin already being taken
  • Dose reduction or cessation must be considered to avoid hypoglycemia

Administration

  • Must be swallowed whole, not crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9 (CYP2C9)
  • Potentiation of blood-glucose-lowering effect may occur with drugs like insulin, ACE inhibitors, anabolic steroids, etc.
  • Weakening of blood-glucose-lowering effect may occur with drugs like barbiturates, corticosteroids, diazoxide, etc.
  • Both acute and chronic alcohol intake may potentiate or weaken the blood-glucose-lowering action
  • Bile acid sequestrant (e.g., Colesevelam) binds to glimepiride, reducing its absorption

Contraindications

  • Hypersensitivity to glimepiride, metformin, or sulfonylureas
  • Pregnancy, breastfeeding
  • Severe impairment of liver function and in dialysis patients for glimepiride
  • Hypersensitivity to metformin or any of its excipients
  • Acute metabolic acidosis, severe renal failure, hepatic insufficiency for metformin

Side Effects

  • Hypoglycemia, prolonged hypoglycemia, temporary visual impairment for glimepiride
  • Gastrointestinal symptoms, liver enzyme elevation, dysgeusia, changes in blood picture for glimepiride
  • Nausea, vomiting, diarrhea, abdominal pain, metallic taste, decrease in vitamin B12 absorption, lactic acidosis, hepatobiliary disorders for metformin

Pregnancy & Lactation

  • Glimepiride must not be taken during pregnancy
  • Diabetes should be treated with insulin during pregnancy
  • Glimepiride must not be taken by breastfeeding women
  • Metformin excreted into milk, decision should be made to discontinue nursing or discontinue metformin

Precautions & Warnings

  • Initial weeks of treatment may increase the risk of hypoglycemia
  • Regular monitoring of thyroid-stimulating hormone levels for patients with hypothyroidism

Use in Special Populations

  • Insufficient data for pediatric use
  • Assessment of GFR before initiation of treatment with metformin

Overdose Effects

  • Acute overdosage may lead to severe life-threatening hypoglycemia for glimepiride
  • Lactic acidosis is a medical emergency and must be treated in hospital for metformin

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Cool (not exceeding 25°C) and dry place
  • Protected from light

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