Sofen 200 mg (Tablet)
Unit Price: ৳ 300.00 (3 x 10: ৳ 9,000.00)
Strip Price: ৳ 3,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sorafenib tosylate |
| Company | Healthcare pharmaceuticals ltd |
Title
- Sorafenib 400mg Tablets
Categories
- Oncology
- Cancer Therapy
Dosage & Administration
- 400 mg tablets taken twice daily without food
- Treatment duration according to clinical benefit or unacceptable toxicity
- Missed dose instructions provided
Indications
- Unresectable Hepatocellular Carcinoma (HCC) treatment
- Advanced Renal Cell Carcinoma (RCC) treatment
Pharmacology
- Kinase inhibitor
- Inhibits tumor cell proliferation
- Inhibition of multiple intracellular and cell surface kinases
- Impacts tumor cell signaling, angiogenesis, and apoptosis
Interaction
- Contraindicated combination with carboplatin and paclitaxel for squamous cell lung cancer
- Effects on UGT and CYP enzyme substrates
- Interactions with various chemotherapeutic agents
- Potential impact on P-glycoprotein substrates
Contraindications
- Severe hypersensitivity to sorafenib or its components
- Contraindicated combination with carboplatin and paclitaxel for squamous cell lung cancer
Side Effects
- Cardiac ischemia
- Hemorrhage
- Hypertension
- Hand-foot skin reaction
- Gastrointestinal perforation
Pregnancy & Lactation
- Potential for fetal harm
- Advisory for women of childbearing potential
Precautions & Warnings
- Cardiac ischemia, infarction
- Risk of Hemorrhage
- Risk of Hypertension
- Risk of Dermatologic Toxicities
- Risks associated with gastrointestinal perforation
- Wound Healing Complications
- Special considerations for concomitant warfarin use
- Use in combination with Carboplatin and Paclitaxel in Non-small Cell Lung Cancer
- Considerations for interactions with UGT1A1 Substrates
- Considerations for interaction with Docetaxel & Doxorubicin
- Impact of hepatic impairment
- Considerations for neomycin co-administration
Use in Special Populations
- Pediatric Use
- Geriatric Use
- Renal impairment
- Hepatic impairment
Overdose Effects
- No specific treatment for overdose
- Observed adverse reactions at high doses
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store at room temperature below 30°C
- Dispense in original bottle