Trexall 50 mg/2 ml (IV Injection or Infusion)
50 mg vial: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Neoplastic Diseases
- Rheumatoid Arthritis
- Psoriasis
Pharmacology
- Inhibits dihydrofolic acid reductase
- Interferes with DNA synthesis and cellular replication
Dosage
- Dosage varies for different diseases
- Oral or intramuscular administration
- Different doses for neoplastic diseases, leukemia, lymphoma, breast cancer, rheumatoid arthritis, and psoriasis
Administration
- Should be taken on an empty stomach
- Avoid taking with milk-rich products
Interaction
- Interacts with NSAIDs, salicylates, phenylbutazone, phenytoin, sulfonamides, penicillin, theophylline, and more
Contraindications
- Alcoholism, chronic liver disease, immunodeficiency syndromes
- Hypersensitivity to methotrexate
- Pregnancy and lactation
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea and abdominal distress
- Malaise and fatigue
Pregnancy & Lactation
- US FDA Pregnancy Category X
- Contradicted in nursing mothers
Precautions & Warnings
- Formulations and diluents containing preservatives must not be used for intrathecal or high dose therapy
- Close monitoring for toxic effects
- Use of leucovorin calcium if adverse reactions occur
Use in Special Populations
- Benefits and risks must be weighed for pediatric and geriatric patients
Overdose Effects
- Leucovorin is indicated to counteract the effect of overdosages
Therapeutic Class
- Antidote preparations
- Immunosuppressant
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light and moisture