Epirubin 2 mg/ml (IV Infusion)
10 mg vial: ৳ 950.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Epirubicin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Adjuvant therapy
- Axillary node tumor
- Breast cancer
Pharmacology
- Cytotoxic
- DNA/RNA synthesis inhibition
- Topoisomerase II inhibition
- Free radicals generation
- Plasma protein binding
Dosage & Administration
- Intravenous infusion
- 3-to 4-week cycles
- Total dose given on day 1 or divided on days 1 and 8
- 100 to 120 mg/m² dose
- CEF-120 regimen
- FEC-100 regimen
- Prophylactic antibiotic therapy
Interaction
- Cardioactive compounds monitoring
- Cimetidine interaction
- Combination with other cytotoxic drugs
- Paclitaxel combination
- Docetaxel combination
- Radiation therapy effect
- Hepatic function impact
Contraindications
- Hypersensitivity to Epirubicin or anthracyclines/anthracenediones
Side Effects
- Myelosuppression
- Cardiotoxicity
- Alopecia
- Hyperpyrexia
- Lethargy
- Amenorrhoea
- Nausea
- Vomiting
- Diarrhea
- Fever
- Rash
- Anorexia
- Reddish appearance of urine
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in human milk
Precautions & Warnings
- Storage conditions impact
- Physician supervision
- Baseline assessment
- Blood counts monitoring
- Cardiac function monitoring
- Supportive care necessity
- Cardiotoxicity monitoring
Use in Special Populations
- Dosage adjustments based on toxicities
- Bone marrow dysfunction impact
- Hepatic/renal impairment recommendations
- Pediatric use considerations
- Geriatric use considerations
Overdose Effects
- Supportive treatment
- Delayed CHF observation
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Refrigerated storage
- Avoid freezing
- Protection from light