Leufol 10 mg/ml (IM/IV Injection)
50 mg vial: ৳ 625.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists
- Calcium folinate rescue
- Treatment of megaloblastic anaemias due to various causes
Composition
- 6.249 mg of Calcium Folinate Hydrate BP equivalent to 5 mg of Folinic Acid
- 18.746 mg of Calcium Folinate Hydrate BP equivalent to 15 mg of Folinic Acid
Pharmacology
- Calcium salt of folinic acid
- Metabolite and active form of folic acid
- Cofactor for 1-carbon transfer reactions
- Involvement in biosynthesis of purine and pyrimidines of nucleic acids
- Potent antidote for hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
- Ready conversion to other tetrahydrofolic acid derivatives
Dosage & Administration
- Recommended dosage for calcium folinate rescue
- Recommended dosage for neutralising the immediate toxic effects of folic acid antagonists
- Recommended dosage for treatment of megaloblastic anaemia
- Use in children and adolescents
Interaction
- Potential interaction with antiepileptic medications
- Caution required during concurrent administration with fluoropyrimidine
Contraindications
- Hypersensitivity to calcium folinate or its components
- Pernicious anemia or other megaloblastic anemia with vitamin B12 deficiency
- Rare hereditary problems of galactose intolerance, lapp lactase deficiency, or glucose-galactose malabsorption
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Use in pregnant women
- Excretion in human milk
Precautions & Warnings
- Use with methotrexate or 5-FU under supervision of experienced clinician
- Administration timing for folic acid antagonist overdosage treatment
- Concurrent use with folic acid antagonists
- Measures to ensure prompt excretion of methotrexate
Overdose Effects
- Nullification of the chemotherapeutic effect of folic acid antagonists
- Appropriate supportive care for overdosage
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of reach of children