Ranolin XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 16.05 (2 x 10: ৳ 321.00)
Strip Price: ৳ 160.50

Medicine Details

Category Details
Generic Ranolazine
Company Square pharmaceuticals plc

Indications

  • Treatment of chronic angina
  • Should be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers
  • Decreases angina episodes in patients with coronary artery disease
  • Effect on angina rate or exercise tolerance is smaller in women than men

Pharmacology

  • Has anti-ischemic and antianginal effects
  • Does not depend upon reductions in heart rate or blood pressure
  • Inhibits the cardiac late sodium current (INa)
  • Prolongs the QT interval
  • Inhibits IkR prolonging the ventricular action potential
  • Absorption: Cmax - 2-5 h, Half-life: 6-22 h, Distribution: 62% bound to human plasma proteins, Metabolism and Excretion: Metabolized mainly by CYP3A and CYP2D6, Rapid and extensive metabolism in the liver and intestine

Dosage & Administration

  • Initiate at 500 mg twice daily and increase to 1000 mg twice daily if needed
  • Take with or without meals
  • Swallow whole, do not crush, break or chew
  • Maximum recommended daily dose is 1000 mg twice daily
  • Safety and effectiveness not established for pediatric use

Interaction

  • Avoid use with strong CYP 3A inhibitors
  • Limit maximum dose with moderate CYP 3A inhibitors
  • Do not use with CYP 3A inducers
  • May need to lower dose with P-gp inhibitors
  • May require reduced doses when used with other drugs

Contraindications

  • Pre-existing QT prolongation
  • Hepatic impairment
  • Taking QT prolonging drugs
  • Taking potent and moderately potent CYP3A inhibitors

Side Effects

  • Bradycardia
  • Palpitations
  • Tinnitus
  • Vertigo
  • Abdominal pain
  • Dry mouth
  • Vomiting
  • Peripheral edema
  • Dyspnea
  • Hypotension
  • Orthostatic hypotension

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate studies assessing the effect on the developing fetus
  • No adequate well-controlled studies in pregnant women
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus
  • Not known whether excreted in human milk
  • Consideration for nursing mother

Precautions & Warnings

  • Blocks QTc and prolongs the QTc interval in a dose-related manner
  • No increased risk of proarrhythmia or sudden death in acute coronary syndrome population
  • Increased plasma concentrations of digoxin when co-administered
  • Caution when co-administering with P-gp inhibitors
  • Exercise caution when co-administering with P-gp inhibitors such as ritonavir or cyclosporine

Overdose Effects

  • Dose-related increases in dizziness, nausea, and vomiting
  • Produces diplopia, paresthesia, confusion, and syncope
  • Continuous ECG monitoring may be warranted
  • Hemodialysis is unlikely to be effective

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

  • Keep below 30°C
  • Away from light & moisture
  • Keep out of the reach of children

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