Ranola 500 mg (Tablet (Extended Release))

Unit Price: ৳ 16.05 (5 x 12: ৳ 963.00)
Strip Price: ৳ 192.60

Medicine Details

Category Details
Generic Ranolazine
Company General pharmaceuticals ltd

Title

  • Ranola

Categories

  • Medicine
  • Pharmaceuticals
  • Therapeutic

Description

  • Ranola is indicated for the treatment of chronic angina. It may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers
  • Has anti-ischemic and anti-anginal effects
  • Available in tablet form
  • Prolongs QT interval, so reserved for patients who have not achieved an adequate response with other antianginal drugs

Dosage and Administration

  • Initiate dosing at 500 mg twice daily and increase to 1000 mg twice daily if needed
  • Swallow tablets whole, do not crush, break or chew
  • Maximum recommended daily dose is 1000 mg twice daily

Interaction

  • Do not use with strong CYP 3A inhibitors
  • Limit maximum dose with moderate CYP 3A inhibitors
  • May need to lower the dose when used with P-gp inhibitors or drugs metabolized by CYP2D6

Contraindications

  • Contraindicated in patients with pre-existing QT prolongation or hepatic impairment
  • Contraindicated with QT prolonging drugs and potent CYP3A inhibitors

Side Effects

  • Bradycardia
  • Palpitations
  • Tinnitus
  • Vertigo
  • Abdominal pain
  • Dry mouth
  • Vomiting
  • Peripheral edema
  • Dyspnea
  • Hypotension
  • Orthostatic hypotension

Pregnancy and Lactation

  • Pregnancy Category C
  • Use during pregnancy only when potential benefit justifies potential risk to fetus
  • It is not known whether ranolazine is excreted in human milk

Precautions and Warnings

  • Blocks QTc and prolongs the QTc interval in a dose-related manner
  • Co-administration with digoxin increases plasma concentrations of digoxin
  • Caution should be exercised when co-administering with P-gp inhibitors

Overdose Effects

  • Dose-related increases in dizziness, nausea, and vomiting
  • Produces diplopia, paresthesia, confusion, and syncope at high intravenous exposure

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

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