Emparol-M 5 mg+500 mg (Tablet)
Unit Price: ৳ 15.00 (2 x 7: ৳ 210.00)
Strip Price: ৳ 105.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Drug international ltd |
Product Name
- Emparol-M Tablet
Category
- Medicine
- Diabetes management
- Oral hypoglycemic preparations
Dosage Form
- Tablet
- Film Coated Tablet
- Extended-release Formulation
Ingredients
- Empagliflozin
- Metformin Hydrochloride
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on Metformin alone
- In combination with other diabetes medicinal products
- Already being treated with Empagliflozin and Metformin separately
Mode of Action
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Twice daily with meals
- Gradual dose escalation
- Individualized starting dose
- Switching from other treatments
- Extended-release formulations
- Renal impaired patient assessment
- Pediatric patient safety
- Maximum recommended daily doses
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Positive Urine Glucose Test
- Drugs that Reduce Metformin Clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Hypotension conditions
- Severe renal failure
- Acute conditions altering renal function
- Tissue hypoxia-related diseases
- Hepatic impairment
- Alcohol intoxication
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection variations
- Thirst
- Changes in taste
- Pruritus
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine/Glomerular filtration rate
- Increased Haematocrit
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment
- Urinary tract infections and genital mycotic infections
- Hypoglycemia risk
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity at high single and multiple doses
- Lactic acidosis medical emergency
- Treatment methods for overdose
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children