Emparol-M 5 mg+500 mg (Tablet)

Unit Price: ৳ 15.00 (2 x 7: ৳ 210.00)
Strip Price: ৳ 105.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Drug international ltd

Product Name

  • Emparol-M Tablet

Category

  • Medicine
  • Diabetes management
  • Oral hypoglycemic preparations

Dosage Form

  • Tablet
  • Film Coated Tablet
  • Extended-release Formulation

Ingredients

  • Empagliflozin
  • Metformin Hydrochloride

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on Metformin alone
  • In combination with other diabetes medicinal products
  • Already being treated with Empagliflozin and Metformin separately

Mode of Action

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Twice daily with meals
  • Gradual dose escalation
  • Individualized starting dose
  • Switching from other treatments
  • Extended-release formulations
  • Renal impaired patient assessment
  • Pediatric patient safety
  • Maximum recommended daily doses

Interaction

  • Diuretics
  • Insulin or Insulin Secretagogues
  • Positive Urine Glucose Test
  • Drugs that Reduce Metformin Clearance
  • Carbonic Anhydrase Inhibitors
  • Drugs Affecting Glycemic Control
  • Alcohol

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Hypotension conditions
  • Severe renal failure
  • Acute conditions altering renal function
  • Tissue hypoxia-related diseases
  • Hepatic impairment
  • Alcohol intoxication
  • Alcoholism

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Urinary tract infection variations
  • Thirst
  • Changes in taste
  • Pruritus
  • Rash
  • Increased urination
  • Increased serum lipids
  • Volume depletion
  • Urticaria
  • Dysuria
  • Increased blood creatinine/Glomerular filtration rate
  • Increased Haematocrit
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment
  • Urinary tract infections and genital mycotic infections
  • Hypoglycemia risk
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity at high single and multiple doses
  • Lactic acidosis medical emergency
  • Treatment methods for overdose

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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