Empazin M 5 mg+500 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Adjunct treatment for type 2 diabetes mellitus
- Insufficiently controlled on maximally tolerated dose of Metformin alone
- Combination therapy for diabetes management
- Already being treated with Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Twice daily with meals
- Individualized dosage based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
- Recommended individualized starting dose based on current drug regimen
- Extended-release formulations available
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Monitoring glycemic control
- Drugs that reduce Metformin clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection (including pyelonephritis and urosepsis)
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine/Glomerular filtration rate
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- Toxicity studies
- Lactic acidosis risk
- Hypoglycaemia risk
- Emergency treatment
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children