Doxomate 200 mg (Tablet)

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Doxophylline
Company Pacific pharmaceuticals ltd
Also available as
Doxomate 400 mg tablet

Title

  • Doxomate

Categories

  • Medicine
  • Bronchodilator
  • Respiratory medication
  • Phosphodiesterase inhibitor

Description

  • Used for bronchial asthma, bronchospasm, COPD, and pulmonary disease with spastic bronchial component
  • Structurally differs from Theophylline due to the presence of a dioxolane group in position 7
  • Selectively inhibits phosphodiesterase 4, relaxes bronchial smooth muscle
  • Reports of inhibition of platelet activating factor (PAF) and generation of leukotriene production
  • Dosage for elderly, adults, and children based on age and weight
  • Contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives, acute myocardial infarction, hypotension, and during lactation
  • Possible side effects include nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, and more
  • Animal tests have shown the active ingredient does not interfere with pre and postnatal growth, but use during pregnancy should be evaluated carefully
  • Does not affect the patient's alertness and ability to drive and use machines
  • Caution needed in patients with factors that may influence the clearance of xanthine derivatives, cardiac disease, hypertension, and renal impairment
  • Severe cardiac arrhythmias and tonic-clonic seizure may occur in case of overdose

Indications

  • Bronchial asthma
  • Bronchospasm
  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary disease with spastic bronchial component

Pharmacology

  • Novel bronchodilator
  • Selective inhibits phosphodiesterase 4
  • Reports of inhibition of platelet activating factor (PAF) and leukotriene production

Dosage administration

  • Dosage for elderly: 200 mg tablet two or three times daily
  • Dosage for adults: 400 mg tablet two or three times daily or as prescribed
  • Dosage for children based on age and weight, syrup or tablet

Interactions

  • Avoid administration with other xanthine preparations and limit caffeine consumption
  • Exercise caution with ephedrine or other sympathomimetic drugs
  • Concurrent administration of certain drugs may reduce hepatic clearance
  • Phenytoin, other anticonvulsants, and cigarette smoking may increase clearance

Contraindications

  • Known hypersensitivity to the drug or other xanthine derivatives
  • Acute myocardial infarction
  • Hypotension
  • During lactation

Side effects

  • Nausea
  • Vomiting
  • Epigastric pain
  • Headache
  • Irritability
  • Insomnia
  • Tachycardia
  • Hyperglycemia
  • Albuminuria

Pregnancy lactation

  • Animal tests show no interference with pre and postnatal growth
  • Use during pregnancy should be evaluated carefully case by case
  • Contraindicated during lactation

Precautions warnings

  • Factors may reduce hepatic clearance with increased plasma levels
  • Caution in patients with cardiac disease, hypertension, and renal impairment

Overdose effects

  • Severe cardiac arrhythmias
  • Tonic-clonic seizure

Therapeutic class

  • Bronchodilator
  • Methyl xanthine derivatives

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children
  • Use only on prescription of specialist physician

Related Brands