Doxomate 400 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of bronchial asthma
- Treatment of bronchospasm
- Treatment of chronic obstructive pulmonary disease (COPD)
- Treatment of pulmonary disease with spastic bronchial component
Pharmacology
- Doxophylline selectively inhibits phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Inhibits platelet activating factor (PAF)
- Inhibits leukotriene production
Dosage & Administration
- Elderly dosage: 200 mg tablet two or three times daily
- Adult dosage: 400 mg tablet two or three times daily or as prescribed
- Children dosage (above 12 years): 10 ml syrup or 200 mg tablet two or three times daily
- Children dosage (6-12 years): 6-9 mg/kg body weight two times daily
Interaction
- Avoid administration with other xanthine preparations
- Limit consumption of beverages and food containing caffeine
- Exercise caution when administering with ephedrine or other sympathomimetic drugs
- Concurrent administration with erythromycin, TAO, lincomycin, etc., may reduce hepatic clearance
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia
- Albuminuria
Pregnancy & Lactation
- Animal tests have shown no interference with pre and postnatal growth
- Insufficient clinical evidence for use during pregnancy
- Contraindicated during lactation
- No impact on driving or machine use
Precautions & Warnings
- Factors influencing hepatic clearance may require dosage adjustment
- Caution in patients with cardiac disease
- Caution in patients with hypertension
- Monitoring blood levels for control of therapeutic range
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Discontinuation of treatment required
- No specific antidote
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Keep in dry place away from light and heat
- Keep out of reach of children
- Use only on prescription of specialist physician