Metazine MR 35 mg (Tablet (Modified Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)

Strip Price: ৳ 80.00

Medicine Details

Category	Details
Generic	Trimetazidine dihydrochloride
Company	Beximco pharmaceuticals ltd

Indications

Add-on therapy for stable angina pectoris
Symptomatic treatment
Inadequately controlled patients
Intolerant to first-line antianginal therapies

Pharmacology

First 3- keto acyl CoA thiolase inhibitor (KAT)
Metabolic anti-ischemic agent
Inhibition of fatty acid pathway
Transfer of oxygen to glucose pathway
Enhanced energy production
Prevention of angina pectoris

Dosage & Administration

Recommended dose of 35mg twice daily
Recommended dose of 20mg thrice daily during meals
Assessment of benefit after three months
Discontinuation in absence of treatment response

Interaction

No reported drug interactions
No interaction with beta-blockers
No interaction with calcium antagonists
No interaction with nitrates
No interaction with heparin
No interaction with hypolipidemic agents
No interaction with digitalis preparation

Contraindications

Hypersensitivity to active substance or excipients
Parkinson’s disease
Parkinsonian symptoms
Tremors
Restless legs movement disorders
Severe renal impairment

Side Effects

Dizziness
Headache
Abdominal pain
Diarrhoea
Dyspepsia
Nausea
Vomiting
Rash
Pruritus
Urticaria
Asthenia

Pregnancy & Lactation

Precautionary avoidance during pregnancy
No data on use in pregnant women
No direct or indirect harmful effects in animal studies
Precautionary avoidance during breast-feeding
Unknown excretion in human milk

Precautions & Warnings

Not curative treatment for angina attacks
Not initial treatment for unstable angina pectoris
Not a treatment for myocardial infarction

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

Keep in a dry place
Away from light and heat
Keep out of the reach of children

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