Alphalok 1 mg (Tablet)

Unit Price: ৳ 4.00 (3 x 14: ৳ 168.00)
Strip Price: ৳ 56.00

Medicine Details

Category Details
Generic Prazosin hydrochloride
Company Opsonin pharma ltd
Also available as
Alphalok 2 mg tablet Alphalok xr 25 mg tablet Alphalok xr 5 mg tablet

Indications

  • Treatment of hypertension
  • Treatment of left ventricular failure
  • Treatment of Raynaud's phenomenon and Raynaud's disease
  • Adjunct in the symptomatic treatment of urinary obstruction caused by benign prostatic hyperplasia

Pharmacology

  • Selective inhibition of postsynaptic alpha-1-adrenoreceptors in vascular smooth muscle
  • Reduction in total peripheral vascular resistance
  • Reduction in left ventricular filling pressure
  • Reduction in cardiac impedance
  • Augmentation of cardiac output

Dosage & Administration

  • Adjust dosage based on patient's individual toleration
  • Starting dose for hypertension: 0.5 mg once daily
  • Starting dose for left ventricular failure: 0.5 mg two, three, or four times a day
  • Starting dose for Raynaud's phenomenon/disease: 0.5 mg twice daily
  • Starting dose for benign prostatic hyperplasia: 0.5 mg twice daily
  • Dosage titration steps may be performed every two or three days

Interaction

  • No adverse drug interaction reported with various classes of drugs including cardiac glycosides, hypoglycemic agents, tranquilizers, antiarrhythmic agents, and analgesics

Contraindications

  • Known sensitivity to quinazolines

Side Effects

  • Common reactions: dizziness, headache, drowsiness, lack of energy, weakness, palpitations, nausea
  • Other reactions: vomiting, diarrhea, edema, orthostatic hypotension, dyspnea, faintness, tachycardia, nervousness, rash, alopecia, urinary frequency, impotence, blurred vision, epistaxis, dry mouth, fever

Pregnancy & Lactation

  • No teratogenic effects seen in animal testing
  • Excreted in small amounts in human milk

Precautions & Warnings

  • Caution advised for patients with postural hypotension
  • Careful adjustment of diuretic dosage in left ventricular failure patients
  • Close monitoring of blood pressure during administration for Raynaud's phenomenon/disease and benign prostatic hyperplasia
  • Not recommended for use in children under 12 years

Use in Special Populations

  • Not recommended in the treatment of left ventricular failure due to mechanical obstruction or recent myocardial infarction

Overdose Effects

  • Support of the cardiovascular system is of first importance
  • Renal function should be monitored and supported

Therapeutic Class

  • Alpha adrenoceptor blocking drugs

Storage Conditions

  • Store below 30°C
  • Keep away from light and moisture
  • Keep away from children's reach

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