Trimet-MR 35 mg (Tablet (Modified Release))

Unit Price: ৳ 7.00 (2 x 14: ৳ 196.00)
Strip Price: ৳ 98.00

Medicine Details

Category Details
Generic Trimetazidine dihydrochloride
Company Drug international ltd
Also available as
Trimet 20 mg tablet

Indications

  • Add-on therapy for stable angina pectoris
  • Symptomatic treatment for inadequately controlled patients
  • Intolerant to first-line antianginal therapies

Pharmacology

  • First 3-keto acyl CoA thiolase inhibitor
  • Metabolic anti-ischemic agent
  • Inhibits fatty acid pathway
  • Transfers oxygen to glucose pathway
  • Increases heart activity
  • Prevents production of lactic acid

Dosage & Administration

  • Recommended dose of 35 mg twice daily or 20 mg thrice daily during meals
  • Assess benefit after three months
  • Discontinue if no treatment response

Interaction

  • No reported drug interactions so far
  • No interaction with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents, or digitalis preparation

Contraindications

  • Hypersensitivity to active substance or excipients
  • Patients with Parkinson’s disease or parkinsonian symptoms
  • Severe renal impairment

Side Effects

  • Common side effects: dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea, vomiting, rash, pruritus, urticaria, asthenia

Pregnancy & Lactation

  • No data on use in pregnant women
  • Animal studies show no harmful effects
  • Preferable to avoid use during pregnancy
  • Unknown excretion in human milk
  • Risk to newborns/infants cannot be excluded
  • Should not be used during breast-feeding

Precautions & Warnings

  • Not a curative treatment for angina attacks
  • Not an initial treatment for unstable angina pectoris
  • Not a treatment for myocardial infarction

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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