Orsema 0.25 mg/0.188 ml (SC Injection)

0.25 mg pre-filled syringe: ৳ 350.00

Medicine Details

Category Details
Generic Semaglutide
Company Incepta pharmaceuticals ltd
Also available as
Orsema 05 mg injection Fitaro 1 mg injection Fitaro 17 mg injection Fitaro 24 mg injection Fitaro 025 mg injection Fitaro 05 mg injection

Title and Categories

  • Orsema Tablet
  • Medicine
  • Pharmaceutical

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Reducing risk of cardiovascular events in diabetes mellitus patients
  • Weight management for obesity patients with comorbid conditions

Pharmacology

  • GLP-1 analogue
  • Stimulates insulin secretion
  • Reduces blood glucose in a glucose-dependent manner
  • Reduces appetite and body weight
  • Delays gastric emptying

Dosage and Administration

  • Tablet to be taken at least 30 minutes before first intake of the day
  • Starter dose of 3 mg once daily for 30 days
  • Maintenance dose of 7 mg once daily for diabetes
  • Injection starting dose of 0.25 mg once weekly, dosage escalation
  • Weekly administration at any time with or without meals
  • Switching patients between tablet and injection

Interaction

  • Delays gastric emptying
  • Potential impact on oral medicinal product absorption
  • Caution with oral meds requiring rapid GI absorption

Contraindications

  • Hypersensitivity to active substance or excipients

Side Effects

  • Hypoglycemia with insulin or sulfonylurea
  • Gastrointestinal disorders
  • Nausea, diarrhea, vomiting, abdominal pain, constipation
  • Allergic reactions, injection site reactions, lipodystrophy, pruritus, rash

Pregnancy and Lactation

  • Not to be used during pregnancy
  • Discontinue at least 2 months before planned pregnancy
  • Avoid during breastfeeding

Precautions and Warnings

  • Not for type 1 diabetes or diabetic ketoacidosis
  • Prompt discontinuation in suspected pancreatitis
  • Monitoring for diabetic retinopathy

Use in Special Populations

  • Safety and efficacy in children and adolescents not established
  • No dose adjustment based on age
  • No dose adjustment for renal impairment except end-stage
  • No dose adjustment for hepatic impairment, caution needed

Overdose Effects

  • Reported overdoses up to 4 mg in a single dose and week
  • Most common reaction is nausea
  • No specific antidote, supportive treatment for symptoms
  • Dose adjustment with other diabetes medications
  • Guidelines for missed doses

Therapeutic Class

  • GLP-1 receptor agonists

Storage Conditions

  • Store at 2°C to 8°C in a refrigerator
  • Do not freeze
  • Keep out of reach of children

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