Taxedol 20 mg/vial (IV Infusion)

20 ml vial: ৳ 4,000.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Beximco pharmaceuticals ltd
Also available as
Taxedol 80 mg injection

Indications

  • Breast Cancer treatment after chemotherapy failure
  • Adjuvant treatment of operable node-positive Breast Cancer
  • Treatment of Non-small Cell Lung Cancer after platinum therapy failure
  • Unresectable, locally advanced or metastatic untreated Non-small Cell Lung Cancer treatment
  • Treatment of Castration-Resistant Prostate Cancer
  • Treatment of Gastric Adenocarcinoma
  • Induction treatment of locally advanced Squamous Cell Carcinoma of the Head and Neck

Pharmacology

  • Antineoplastic agent disrupting the microtubular network
  • Promotes assembly of tubulin into stable microtubules
  • Inhibits disassembly of microtubules
  • Binds to free tubulin

Dosage & Administration

  • Administer intravenously over 1 hour every 3 weeks
  • Follow specific dosage guidelines for different indications
  • Use only a 21 gauge needle to withdraw from the vial
  • Premedicate with oral corticosteroids

Interaction

  • CYP3A4 substrate
  • Metabolism may be modified by concomitant administration of certain compounds

Contraindications

  • Neutrophil counts of <1500 cells/mm3
  • History of severe hypersensitivity reactions to docetaxel or polysorbate 80

Side Effects

  • Infections
  • Neutropenia
  • Anemia
  • Hypersensitivity
  • Thrombocytopenia
  • Neuropathy
  • Dysgeusia
  • Dyspnea
  • Constipation
  • Anorexia
  • Nail disorders
  • Fluid retention
  • Asthenia
  • Pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Mucositis
  • Alopecia
  • Skin reactions
  • Myalgia

Pregnancy & Lactation

  • Potential fetal harm
  • No human milk presence information available

Precautions & Warnings

  • Administered under supervision of experienced physician
  • Higher risk in patients with hepatic impairment
  • Should not be given to patients with neutrophil counts of less than 1,500 cells/mm3

Overdose Effects

  • No known antidote
  • Close monitoring of vital functions
  • Therapeutic G-CSF administration
  • Expectation of bone marrow suppression, peripheral neurotoxicity, and mucositis

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store between 2°C and 25°C
  • Protected from light
  • Freezing does not adversely affect the product

Related Brands