Taxedol 20 mg/vial (IV Infusion)
20 ml vial: ৳ 4,000.00
Medicine Details
Category | Details |
---|---|
Generic | Docetaxel trihydrate |
Company | Beximco pharmaceuticals ltd |
Also available as |
Indications
- Breast Cancer treatment after chemotherapy failure
- Adjuvant treatment of operable node-positive Breast Cancer
- Treatment of Non-small Cell Lung Cancer after platinum therapy failure
- Unresectable, locally advanced or metastatic untreated Non-small Cell Lung Cancer treatment
- Treatment of Castration-Resistant Prostate Cancer
- Treatment of Gastric Adenocarcinoma
- Induction treatment of locally advanced Squamous Cell Carcinoma of the Head and Neck
Pharmacology
- Antineoplastic agent disrupting the microtubular network
- Promotes assembly of tubulin into stable microtubules
- Inhibits disassembly of microtubules
- Binds to free tubulin
Dosage & Administration
- Administer intravenously over 1 hour every 3 weeks
- Follow specific dosage guidelines for different indications
- Use only a 21 gauge needle to withdraw from the vial
- Premedicate with oral corticosteroids
Interaction
- CYP3A4 substrate
- Metabolism may be modified by concomitant administration of certain compounds
Contraindications
- Neutrophil counts of <1500 cells/mm3
- History of severe hypersensitivity reactions to docetaxel or polysorbate 80
Side Effects
- Infections
- Neutropenia
- Anemia
- Hypersensitivity
- Thrombocytopenia
- Neuropathy
- Dysgeusia
- Dyspnea
- Constipation
- Anorexia
- Nail disorders
- Fluid retention
- Asthenia
- Pain
- Nausea
- Diarrhea
- Vomiting
- Mucositis
- Alopecia
- Skin reactions
- Myalgia
Pregnancy & Lactation
- Potential fetal harm
- No human milk presence information available
Precautions & Warnings
- Administered under supervision of experienced physician
- Higher risk in patients with hepatic impairment
- Should not be given to patients with neutrophil counts of less than 1,500 cells/mm3
Overdose Effects
- No known antidote
- Close monitoring of vital functions
- Therapeutic G-CSF administration
- Expectation of bone marrow suppression, peripheral neurotoxicity, and mucositis
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store between 2°C and 25°C
- Protected from light
- Freezing does not adversely affect the product
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