Taxedol 80 mg/vial (IV Infusion)

80 mg vial: ৳ 12,600.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Beximco pharmaceuticals ltd
Also available as
Taxedol 20 mg injection

Indications

  • Breast Cancer treatment
  • Non-small Cell Lung Cancer treatment
  • Castration-Resistant Prostate Cancer treatment
  • Gastric Adenocarcinoma treatment
  • Squamous Cell Carcinoma of the Head and Neck treatment

Pharmacology

  • Acts by disrupting the microtubular network in cells
  • Promotes the assembly of tubulin into stable microtubules
  • Inhibits the disassembly of microtubules
  • Binds to free tubulin, decreasing critical intracellular concentration

Dosage & Administration

  • Administered intravenously over 1 hr every 3 weeks
  • Different dosages for different types of cancer treatment
  • Use 21 gauge needle to withdraw docetaxel from the vial
  • Premedicate with oral corticosteroids
  • Adjust dose as needed

Interaction

  • CYP3A4 substrate
  • Metabolism may be modified by concomitant administration of certain compounds

Contraindications

  • Neutrophil counts of less than 1500 cells/mm3
  • History of severe hypersensitivity reactions to docetaxel or polysorbate 80

Side Effects

  • Infections
  • Neutropenia
  • Anemia
  • Febrile neutropenia
  • Hypersensitivity
  • Thrombocytopenia
  • Neuropathy
  • Dysgeusia
  • Dyspnea
  • Constipation
  • Anorexia
  • Nail disorders
  • Fluid retention
  • Asthenia
  • Pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Mucositis
  • Alopecia
  • Skin reactions
  • Myalgia

Pregnancy & Lactation

  • Can cause fetal harm when administered to pregnant women
  • No information regarding presence in human milk or effects on milk production

Precautions & Warnings

  • Administered under the supervision of an experienced physician
  • Higher risk in patients with hepatic impairment
  • Should not be given to patients with neutrophil counts less than 1500 cells/mm3
  • Risk of severe hypersensitivity reactions
  • Treatment related acute myeloid leukemia may occur

Overdose Effects

  • No known antidote
  • Expect exacerbation of adverse events
  • Primary anticipated complications: bone marrow suppression, peripheral neurotoxicity, mucositis

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store between 2°C and 25°C
  • Protected from light

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