Kaneva 100 mg (Tablet)
Unit Price: ৳ 750.00 (3 x 10: ৳ 22,500.00)
Strip Price: ৳ 7,500.00
Medicine Details
Category | Details |
---|---|
Generic | Erlotinib |
Company | Beximco pharmaceuticals ltd |
Also available as |
Indications
- First-line treatment of metastatic Non-Small Cell Lung cancer (NSCLC) with specific mutations
- Maintenance treatment of locally advanced or metastatic NSCLC
- Treatment of locally advanced or metastatic NSCLC after failure of prior chemotherapy
- First-line treatment of locally advanced or metastatic pancreatic cancer
Description
- Chemical name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)4-quinazolinamine
- Reversible inhibition of EGFR kinase activity
- Prevention of autophosphorylation of tyrosine residues
- Higher binding affinity for specific EGFR mutations
Dosage & Administration
- Recommended daily dose of 150 mg for NSCLC
- Recommended daily dose of 100 mg for pancreatic cancer in combination with gemcitabine
- Dose reduction with concomitant use of strong CYP3A4 inhibitors
- Dose increment with concomitant use of CYP3A4 inducers
Interaction
- Interaction with coumarin-derived anticoagulants
- Metabolism by CYP3A4
- Interaction with CYP3A4 inhibitors
- Pre-treatment with CYP3A4 inducers
Side Effects
- Common adverse reactions: rash, diarrhea, anorexia, fatigue, dyspnea, cough, nausea, vomiting
- Serious adverse reactions: ILD, renal failure, hepatotoxicity, gastrointestinal perforation, skin disorders, myocardial infarction, cerebrovascular accident
Pregnancy & Lactation
- Pregnancy category D
- Potential presence in human milk
- Recommendation to discontinue nursing if on drug
Precautions & Warnings
- Precautions for ILD, renal failure, hepatotoxicity, gastrointestinal perforations, skin disorders, myocardial infarction
- Discontinuation criteria for specific adverse reactions
Use in Special Populations
- No established use in pediatric patients
- Similar safety and efficacy in subjects 65 years and older
Overdose Effects
- Tolerability of single and repeated doses
- Severe adverse reactions above recommended dose
- Symptomatic treatment for suspected overdose
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store at temperature not exceeding 30°C
- Protection from light and moisture