Kaneva 100 mg (Tablet)

Unit Price: ৳ 750.00 (3 x 10: ৳ 22,500.00)
Strip Price: ৳ 7,500.00

Medicine Details

Category Details
Generic Erlotinib
Company Beximco pharmaceuticals ltd
Also available as

Indications

  • First-line treatment of metastatic Non-Small Cell Lung cancer (NSCLC) with specific mutations
  • Maintenance treatment of locally advanced or metastatic NSCLC
  • Treatment of locally advanced or metastatic NSCLC after failure of prior chemotherapy
  • First-line treatment of locally advanced or metastatic pancreatic cancer

Description

  • Chemical name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)4-quinazolinamine
  • Reversible inhibition of EGFR kinase activity
  • Prevention of autophosphorylation of tyrosine residues
  • Higher binding affinity for specific EGFR mutations

Dosage & Administration

  • Recommended daily dose of 150 mg for NSCLC
  • Recommended daily dose of 100 mg for pancreatic cancer in combination with gemcitabine
  • Dose reduction with concomitant use of strong CYP3A4 inhibitors
  • Dose increment with concomitant use of CYP3A4 inducers

Interaction

  • Interaction with coumarin-derived anticoagulants
  • Metabolism by CYP3A4
  • Interaction with CYP3A4 inhibitors
  • Pre-treatment with CYP3A4 inducers

Side Effects

  • Common adverse reactions: rash, diarrhea, anorexia, fatigue, dyspnea, cough, nausea, vomiting
  • Serious adverse reactions: ILD, renal failure, hepatotoxicity, gastrointestinal perforation, skin disorders, myocardial infarction, cerebrovascular accident

Pregnancy & Lactation

  • Pregnancy category D
  • Potential presence in human milk
  • Recommendation to discontinue nursing if on drug

Precautions & Warnings

  • Precautions for ILD, renal failure, hepatotoxicity, gastrointestinal perforations, skin disorders, myocardial infarction
  • Discontinuation criteria for specific adverse reactions

Use in Special Populations

  • No established use in pediatric patients
  • Similar safety and efficacy in subjects 65 years and older

Overdose Effects

  • Tolerability of single and repeated doses
  • Severe adverse reactions above recommended dose
  • Symptomatic treatment for suspected overdose

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Protection from light and moisture

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