Azosil 500 mg (Tablet)

Unit Price: ৳ 35.00 (2 x 6: ৳ 420.00)
Strip Price: ৳ 210.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Silco pharmaceutical ltd
Also available as
Azosil 200 mg suspension

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Otitis media
  • Skin and soft tissue infections
  • Sexually transmitted diseases

Pharmacology

  • Acid-stable
  • Oral bioavailability
  • Time to peak concentration
  • High concentration in phagocytes
  • High concentration in tissues
  • Half-life
  • Biliary excretion
  • Microbial protein synthesis inhibition
  • Activity against gram-positive and gram-negative microorganisms
  • Active against Chlamydia trachomatis
  • Active against Haemophilus influenzae
  • Active against Neisseria gonorrhoeae
  • Active against Mycoplasma pneumoniae
  • Active against Bordetella pertussis
  • Active against Legionella pneumophila
  • Active against anaerobic microorganisms

Dosage

  • 500 mg once daily orally for 3 days
  • Oral dose for sexually transmitted diseases caused by Chlamydia trachomatis
  • Different oral doses for children based on body weight
  • 500 mg intravenous dose for adult patients with community-acquired pneumonia
  • 500 mg intravenous dose for adult patients with pelvic inflammatory disease
  • Safety and effectiveness not established for children or adolescents under 16 years

Administration

  • Oral administration
  • Reconstitution procedure for suspension
  • Should be taken at least 1 hour before or 2 hours after meal

Interaction

  • Interaction with antacids
  • Interaction with carbamazepine
  • Interaction with cyclosporin
  • Interaction with digoxin
  • Interaction with ergot derivatives
  • Interaction with methylprednisolone
  • Interaction with theophylline
  • Interaction with warfarin
  • Interaction with terfenadine

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotics
  • Co-administration with ergot derivatives
  • Patients with hepatic diseases

Side effects

  • Gastrointestinal side effects
  • Nausea
  • Abdominal discomfort
  • Vomiting
  • Flatulence
  • Diarrhoea
  • Allergic reactions
  • Rash
  • Photosensitivity
  • Reversible elevations in liver transaminases
  • Cholestatic jaundice
  • Reductions in neutrophil counts
  • Hearing impairment

Pregnancy and lactation

  • Pregnancy Category B
  • No adequate and well controlled studies in pregnant women
  • Caution in nursing women

Precautions and warnings

  • Rare serious allergic reactions
  • Angioneurotic oedema
  • Anaphylaxis

Use in special populations

  • No dose adjustment needed in patients with mild renal impairment
  • Caution in using azithromycin in patients with severe renal impairment
  • Not to be used in patients with hepatic disease
  • No effect on a patient’s ability to drive or operate machinery

Overdose effects

  • Typical symptoms of overdosage with macrolide antibiotics
  • Hearing loss
  • Severe nausea
  • Vomiting
  • Diarrhoea
  • Gastric lavage indicated

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical structure

  • Molecular formula: C38H72N2O12
  • Chemical structure image available

Common questions

  • Mechanism of action
  • Uses
  • Common side effects
  • Storage and disposal instructions
  • Diarrhea as a side effect
  • Safety
  • Antibiotic classification
  • When to consult a doctor
  • Quick tips for usage

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