Azosil 200 mg/5 ml (Powder for Suspension)
15 ml bottle: ৳ 85.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Silco pharmaceutical ltd |
| Also available as |
Title
- Azosil 200 mg/5 ml Suspension
Categories
- Medicine
- Health & Wellness
- Pharmaceutical
Description
- Azosil is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue infections, and sexually transmitted diseases. It is readily absorbed and has a prolonged terminal half-life. Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis. The recommended dosage for adults and children varies based on the condition being treated. The administration involves reconstitution of the suspension and the medication should be taken 1 hour before or 2 hours after a meal. Azosil has several interactions with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine. It is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives, and in patients with hepatic diseases. The medicine is generally well tolerated with a low incidence of side effects, primarily gastrointestinal in origin, but rare reports of serious hypersensitivity reactions have been noted. Azithromycin is Pregnancy Category B and caution should be exercised when administered to nursing women. Like other macrolides, rare serious allergic reactions may occur, and special precautions are needed for patients with renal impairment. Overdose effects may include hearing loss, severe nausea, vomiting, and diarrhea.
Color Options
- White
Weight
- 200 mg/5 ml
Dimensions
- Bottle size: 100 ml
Dosage Instructions
- 500 mg once daily orally for 3 days for adults
- 10 mg/kg body weight once daily for 3 days for child over 6 months
Mode of Action
- Readily absorbed
- Greater absorption on an empty stomach
- Transported to the site of infection by phagocytes
- Binds to the 50S ribosomal subunit of susceptible microorganisms
- Interferes with microbial protein synthesis
- Active against aerobic and facultative gram-positive and gram-negative microorganisms
- Acts by ion trapping and high lipid solubility
Pharmacology
- Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms
- Plasma clearance of 630 mL/min
- Terminal elimination half-life of 68 hours
- Biliary excretion of azithromycin, predominantly unchanged
- Approximately 6% of the administered dose appears as unchanged drug in urine
Indications
- Lower respiratory tract infections including bronchitis and pneumonia
- Upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted diseases in men and women
Age Group
- Adults
- Children
Usability Features
- Oral administration
- Reconstitution procedure of suspension
- Should be taken 1 hour before or 2 hours after meal
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Interaction
- Interaction with antacids
- Interaction with carbamazepine
- Potential interference with the metabolism of cyclosporin
- Impact on the metabolism of digoxin
- Theoretical possibility of ergotism
- No significant effect on the pharmacokinetics of methylprednisolone
- No evidence of pharmacokinetic interaction when co-administered with theophylline
- Did not alter the anticoagulant effect of warfarin
- No significant changes in cardiac repolarization when co-administered with terfenadine
Contraindications
- Hypersensitivity to Azithromycin or any other macrolide antibiotic
- Co-administration of ergot derivatives
- Patients with hepatic diseases
Side Effects
- Gastrointestinal side effects (e.g., nausea, abdominal discomfort, vomiting, diarrhea)
- Allergic reactions such as rash or photosensitivity
- Rare reports of serious hypersensitivity reactions
- Reversible elevations in liver transaminases
- Rare cases of cholestatic jaundice
- Transient mild reductions in neutrophil counts
- Reversible hearing impairment in some patients with higher doses used for prolonged periods
Pregnancy & Lactation
- Pregnancy Category B
- No evidence of harm to the fetus in animal reproduction studies
- Caution in use during pregnancy if adequate alternatives are available
- Caution in administration to nursing women
Precautions & Warnings
- Rare serious allergic reactions reported
- Caution needed for patients with renal impairment
- Not recommended for use in patients with hepatic disease
Overdose Effects
- Symptoms may include hearing loss, severe nausea, vomiting, and diarrhea
- Gastric lavage and general supportive measures indicated
Storage Condition
- Dry place away from light and heat