Esonam 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (6 x 10: ৳ 360.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Esomeprazole
Company Silco pharmaceutical ltd
Also available as
Esonam 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Mode of Action

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Inhibits H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Absorption: Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver by CYP enzyme system
  • Excretion: Plasma elimination half-life of approximately 1–1.5 hours
  • Combination Therapy with Antimicrobials increases AUC and Cmax
  • No clinically significant interactions with certain drugs

Dosage

  • Oral dosage form for various conditions
  • 20 mg or 40 mg Once Daily for specified periods
  • IV Injection or IV infusion for specific patient groups and conditions

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension usage instructions
  • IV Injection preparation and administration

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of gastric acid secretion may interfere with drug absorption
  • Potential interference with the absorption of certain drugs
  • Drug interaction studies with specific medications

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Common adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if essential use is considered

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Esonam

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy observed between elderly and younger individuals
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Acute toxicity signs observed in animal studies
  • No reports of overdose with Esonam
  • No specific antidote known
  • Symptomatic and supportive treatment recommended in case of overdosage

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure represented by an image

Common Questions about Esonam 20 mg Capsule

  • Description of Esonam 20 mg Capsule
  • Multiple uses of Esonam 20 mg Capsule
  • Common side effects of Esonam 20 mg Capsule
  • Guidance on use during pregnancy or breastfeeding
  • Information on onset of action and quick tips

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