Losart-P 50 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Silco pharmaceutical ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Starting dose of 25 mg once daily for patients with intravascular volume-depletion
- Lower starting dose of 25 mg once daily for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor found in many tissues and reduces vasoconstriction and release of aldosterone
Interaction
- Reduced levels with rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics, supplements, or salt substitutes
- Attenuated antihypertensive effect by indomethacin
- Increased risk of renal impairment with concomitant use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic
Contraindications
- Pregnant women
- Patients hypersensitive to any component of the product
- Administration with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Upper respiratory infection
- Fatigue
- Edema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus if administered during second or third trimesters
- Unknown excretion in human milk
- Adverse effects on nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death when used during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose of 25 mg once daily in patients with moderate to severe renal impairment or on dialysis
- Lower dose for patients with a history of hepatic impairment
- Contraindicated in pregnancy and in patients hypersensitive to losartan
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children