Metfosil 500 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Silco pharmaceutical ltd
Also available as
Metfosil 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Reduction of diabetic complications

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Improves insulin sensitivity
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose of 500 mg or 850 mg
  • Maximum daily doses
  • Dosage for adults and children
  • Metformin immediate release tablet
  • Metformin extended release tablet
  • Dosage adjustments for renal impaired patients

Interaction

  • Co-administration with Furosemide and Nifedipine
  • Effects on cationic drugs and renal tubular transport systems
  • Interaction with certain drugs leading to hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function and tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Vitamin B12 absorption decrease
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes associated risk during pregnancy
  • Recommendation for insulin usage during pregnancy
  • Excretion into breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowering of vitamin B12 level
  • Risk of hypoglycemia in combination therapy with insulin
  • Surgery and clinical investigation precautions
  • Dehydration and serious infections precautions
  • Annual estimation of Vitamin B-12 levels
  • Hypoglycemia possibility with combined therapy
  • Interaction with cimetidine and anticoagulants

Use in Special Populations

  • Adjustment of dosage in elderly subjects
  • Follow-up of effect on growth and puberty in children
  • Particular caution in children aged 10-12 years
  • Assessment of renal function before treatment initiation and regularly thereafter

Overdose Effects

  • Hypoglycemia not seen in doses up to 85 gm
  • Occurrence of lactic acidosis
  • Hemodialysis as the most effective method for treatment

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protected from light and moisture
  • Keep out of the reach of children

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