Mucin-R 150 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Silco pharmaceutical ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcer
- 150 mg twice daily for reflux oesophagitis for up to 8 weeks
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg twice daily for episodic dyspepsia for up to 6 weeks
- 150 mg at night for prevention of recurrences
- 2-4 mg/kg twice daily for children with peptic ulcer
- Ranitidine injection given as a slow intravenous injection or intermittent intravenous infusion
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propranolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Crosses the placenta
- No evidence of impaired fertility or harm to the fetus
- Caution should be exercised when administered to a nursing mother
Precautions & Warnings
- Should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates found similar in elderly patients
- No difference in the incidence of adverse effects in elderly patients
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy should be given as appropriate
- May be removed from the plasma by haemodialysis if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Mucin-R 50 mg diluted to a concentration ≤2.5 mg/mL for slow IV injection
- Mucin-R 50 mg diluted to a concentration ≤0.5 mg/mL for intermittent slow IV infusion
- Mucin-R 150 mg diluted in 250 mL for continuous IV infusion
- Mucin-R for Zollinger-Ellison syndrome or other hypersecretory conditions should be diluted to a concentration ≤2.5 mg/mL
Storage Conditions
- Store in a cool and dry place
- Protect from light