Naxsil E 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)

Strip Price: ৳ 60.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Silco pharmaceutical ltd
Also available as	Naxsil e 500 mg tablet

Relief of signs and symptoms of Osteoarthritis
Relief of signs and symptoms of Rheumatoid arthritis
Relief of signs and symptoms of Ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosage: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg
One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
Increased risk of bleeding complication with warfarin
Inhibition of gastric acid secretion may interfere with the absorption of certain drugs where gastric pH is an important determinant of bioavailability
Effect of high-fat food on absorption of naproxen

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Increased risk of arterial thrombotic events at high doses and in long-term treatment
Gastrointestinal side effects include peptic ulcers, perforation or GI bleeding, nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn's disease
Less frequently observed side effects include gastritis, oedema, hypertension, and cardiac failure

Avoid using with other NSAIDs and cyclooxygenase-2 selective inhibitors
Minimize undesirable effects by using the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors for developing NSAID related gastro-intestinal complications
Increased frequency of adverse reactions in older people especially gastro-intestinal bleeding and perforation
Increased risk of GI bleeding, ulceration or perforation, particularly in older people
Appropriate monitoring and advice required for patients with a history of hypertension and/or mild to moderate congestive heart failure
Long-term administration of NSAIDs can result in renal injury

Caution and possible dosage adjustment in elderly patients due to changes in unbound plasma fraction of naproxen
Not recommended in patients with moderate to severe or severe renal impairment
Close monitoring and possible dose reduction in patients with mild to moderate hepatic impairment

Symptoms related to Naproxen overdose including lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, disorientation, vomiting, and rare occurrences of hypertension, acute renal failure, respiratory depression, and coma
Symptoms related to esomeprazole overdose are transient
Management includes symptomatic and supportive care following a NSAID overdose, particularly with respect to GI effects and renal damage, and no specific antidote is known for esomeprazole overdose