Oltan-A 5 mg+20 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
Category | Details |
---|---|
Generic | Amlodipine besilate olmesartan medoxomil |
Company | Silco pharmaceutical ltd |
Also available as |
Indications
- Treatment of hypertension alone or with other antihypertensive agents
- Lowering blood pressure
- Initial therapy for patients likely to need multiple antihypertensive agents
- Individualized decision for using combination therapy
- Variation of blood pressure goals based on patient's risk
Pharmacology
- Amlodipine as a dihydropyridine calcium channel blocker
- Greater effect on vascular smooth muscle cells than on cardiac muscle cells
- Peripheral arterial vasodilator
- Inhibition of transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle
- Olmesartan Medoxomil as an angiotensin II receptor antagonist
- Blocking vasoconstrictor and aldosterone-secreting effects of angiotensin II
- Selective blocking of AT1 receptor found in various tissues
- Non-inhibition of ACE
Dosage & Administration
- Substitution of individually titrated components
- Flexible dosing with titration
- Initiation with 5/20 mg once daily
- Titration up to a maximum of 10/40 mg once daily
- Lower starting dose of Amlodipine for elderly patients
Interaction
- Possible attenuation of antihypertensive effect by NSAIDs including selective COX-2 inhibitors
- Close monitoring of blood pressure, renal function, and electrolytes
Contraindications
- Co-administration contraindicated with Aliskiren in patients with diabetes
Side Effects
- Common side effects include peripheral edema, headache, flushing, and dizziness
- Potential for causing sprue-like enteropathy
Pregnancy & Lactation
- Pregnancy Category D
- Avoid use in 2nd and 3rd trimester
- Potential fetal death
- Consideration for discontinuation in pregnancy
- Uncertain excretion in human milk
- Assessment of drug importance for nursing mother
Precautions & Warnings
- Caution in volume- or salt-depleted patients for hypotension
- Risk in patients with severe aortic stenosis for vasodilation
- Potential for increased angina or acute MI in patients with severe obstructive coronary artery disease
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No observed differences in safety or effectiveness between elderly and younger subjects
- Lack of studies in patients with renal impairment
- Non-recommended initial therapy in hepatically impaired patients
Overdose Effects
- No available information on human overdosage
Therapeutic Class
- Belongs to combined antihypertensive preparations
Storage Conditions
- Storage below 30°C
- Protection from light
- Keep out of the reach of children