Oltan-A 5 mg+20 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Indications

  • Treatment of hypertension alone or with other antihypertensive agents
  • Lowering blood pressure
  • Initial therapy for patients likely to need multiple antihypertensive agents
  • Individualized decision for using combination therapy
  • Variation of blood pressure goals based on patient's risk

Pharmacology

  • Amlodipine as a dihydropyridine calcium channel blocker
  • Greater effect on vascular smooth muscle cells than on cardiac muscle cells
  • Peripheral arterial vasodilator
  • Inhibition of transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle
  • Olmesartan Medoxomil as an angiotensin II receptor antagonist
  • Blocking vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Selective blocking of AT1 receptor found in various tissues
  • Non-inhibition of ACE

Dosage & Administration

  • Substitution of individually titrated components
  • Flexible dosing with titration
  • Initiation with 5/20 mg once daily
  • Titration up to a maximum of 10/40 mg once daily
  • Lower starting dose of Amlodipine for elderly patients

Interaction

  • Possible attenuation of antihypertensive effect by NSAIDs including selective COX-2 inhibitors
  • Close monitoring of blood pressure, renal function, and electrolytes

Contraindications

  • Co-administration contraindicated with Aliskiren in patients with diabetes

Side Effects

  • Common side effects include peripheral edema, headache, flushing, and dizziness
  • Potential for causing sprue-like enteropathy

Pregnancy & Lactation

  • Pregnancy Category D
  • Avoid use in 2nd and 3rd trimester
  • Potential fetal death
  • Consideration for discontinuation in pregnancy
  • Uncertain excretion in human milk
  • Assessment of drug importance for nursing mother

Precautions & Warnings

  • Caution in volume- or salt-depleted patients for hypotension
  • Risk in patients with severe aortic stenosis for vasodilation
  • Potential for increased angina or acute MI in patients with severe obstructive coronary artery disease

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No observed differences in safety or effectiveness between elderly and younger subjects
  • Lack of studies in patients with renal impairment
  • Non-recommended initial therapy in hepatically impaired patients

Overdose Effects

  • No available information on human overdosage

Therapeutic Class

  • Belongs to combined antihypertensive preparations

Storage Conditions

  • Storage below 30°C
  • Protection from light
  • Keep out of the reach of children

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