Peplo 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Silco pharmaceutical ltd
Also available as
Peplo 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days upon discontinuation

Dosage

  • Various dosage regimens for different conditions and patient populations
  • Oral administration for benign gastric and duodenal ulcer, NSAID-associated duodenal or gastric ulcer, gastro-esophageal reflux disease, long-term management of acid reflux disease, acid-related dyspepsia, prophylaxis of acid aspiration, Zollinger-Ellison syndrome, Helicobacter pylori eradication regimen, and paeditaric use
  • IV injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux oesophagitis, and Zollinger-Ellison syndrome

Administration

  • Directions for use of IV Injection
  • Directions for use of IV Infusion
  • Instructions for reconstitution and intravenous administration

Interaction

  • Effect on absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Monitoring and possible dose adjustment for warfarin or phenytoin
  • Plasma concentration changes during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • Need for excluding malignancy before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea, headache, constipation, nausea/vomiting, and abdominal pain
  • Dizziness, light headedness, and feeling faint
  • Mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms

Pregnancy & Lactation

  • No adverse effects on pregnancy or the fetus/newborn child based on epidemiological studies
  • Safe use during pregnancy
  • No information on passage into breast milk or effects on the neonate
  • Recommendation to discontinue breast-feeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term treatment
  • Potential for concomitant use with methotrexate leading to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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