Rabsil 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Silco pharmaceutical ltd

Therapeutic Class

  • Proton Pump Inhibitor

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Treatment of symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Long-term management of gastro-esophageal reflux disease (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Combination therapy for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion
  • Inhibits the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative GERD is 20 mg once daily for four to eight weeks
  • For long-term management of GERD, maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily
  • Symptomatic treatment of moderate to very severe symptomatic GERD is 10 mg once daily
  • Treatment of Zollinger-Ellison Syndrome: recommended adult starting dose is 60 mg once a day
  • Treatment of H. pylori infection: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily

Administration

  • Should be taken in the morning, before eating
  • Tablets should not be chewed or crushed, but should be swallowed whole

Interaction

  • May interact with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may result in a significant decrease in antifungal plasma levels
  • No interaction with liquid antacids observed
  • PPIs should not be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or any of the excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely to be excreted in human milk

Precautions & Warnings

  • Symptomatic response to therapy does not exclude the presence of gastric or esophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • May modestly increase the risk of hip, wrist, and spine fracture
  • A risk of cross-hypersensitivity reactions with other proton pump inhibitors
  • Hepatic enzyme abnormalities have been seen in clinical trials
  • Severe hypomagnesemia has been reported in patients treated with PPIs
  • May reduce the absorption of vitamin B12
  • Associated with very infrequent cases of subacute cutaneous lupus erythematosus (SCLE)
  • Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumors
  • Not recommended for use in children due to a lack of data on safety and efficacy

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment

Overdose Effects

  • Effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention
  • No specific antidote is known
  • Extensively protein bound and not dialysable
  • Treatment should be symptomatic with general supportive measures

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions

  • What is Rabsil 20 mg Tablet?
  • What is Rabsil 20 mg Tablet used for?
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  • How should I take Rabsil 20 mg Tablet?
  • Can I take Rabsil 20 mg Tablet while pregnant or breastfeeding?
  • What should I do if I overdose on Rabsil 20 mg Tablet?
  • How long should I take Rabsil 20 mg Tablet?
  • Is there anything else I should know about Rabsil 20 mg Tablet?
  • Does Rabsil 20 mg Tablet cause bone problems?
  • Can I take Rabsil 20 mg Tablet with vitamin D?

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