Amlevo 5 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Eskayef pharmaceuticals ltd |
| Also available as | Amlevo 25 mg tablet |
Indications
- Treatment of hypertension
- Lowering blood pressure
Pharmacology
- Calcium channel blocker
- Dihydropyridine calcium antagonist
- Inhibition of calcium influx into vascular smooth muscle and cardiac muscle
- Absorption with Tmax of 6-12 h and bioavailability of 64-90%
- Distribution and volume of distribution similarity
- Metabolism primarily mediated by CYP3A4
- 60% elimination in urine
Dosage & Administration
- Oral route of administration
- Usual initial dose of 2.5 mg once daily
- Maximum dose of 5 mg once daily
- Different initial dose for elderly patients and patients with hepatic insufficiency
- Adjustable dosage for blood pressure goals
- Effective dose in pediatric patients ages 6-17 years
Interaction
- Effects of CYP3A inhibitors and inducers
- Impact on other drugs like simvastatin and immunosuppressants
- Instructions for administration with or without food
- Avoidance of grapefruit products and natural licorice
Contraindications
- Contraindicated in patients with known sensitivity to amlodipine
Side Effects
- Common side effects including difficulty in breathing, dizziness, hypotension, abdominal pain, and edema
- Rare side effects such as diarrhea, back pain, headache, fatigue, and nausea
Pregnancy & Lactation
- Limited available data on amlodipine use in pregnant women
- No adverse effects on the breastfed infant observed
Precautions & Warnings
- Possibility of symptomatic hypotension
- Risk of increased angina or myocardial infarction
- Cautious administration in patients with hepatic failure
- Titration advice for patients with severe hepatic impairment
Overdose Effects
- Expected excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store in a cool and dry place
- Protection from light and moisture
- Keep out of reach of children