Oxima Plus 110 mcg+50 mcg (Inhalation Capsule)

Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)
Strip Price: ৳ 350.00

Medicine Details

Category Details
Generic Indacaterol glycopyrronium
Company Aci limited

Indications

  • Long-term once-daily maintenance bronchodilator treatment for COPD patients
  • Not indicated for acute episodes of bronchospasm
  • Not indicated for asthma

Composition

  • Each dry powder inhaler capsule contains Indacaterol 110 mcg as Indacaterol Maleate INN
  • Each dry powder inhaler capsule contains Glycopyrronium 50 mcg as Glycopyrronium Bromide BP

Pharmacology

  • Combination of Glycopyrronium (an anticholinergic) and Indacaterol (a LABA)
  • Stimulation of intracellular adenyl cyclase for bronchial smooth muscle relaxation
  • Pharmacological effects through inhibition of M3 receptor at the smooth muscle for bronchodilation

Dosage & Administration

  • 1 inhalation once daily for maintenance treatment of COPD in adults
  • Use at the same time every day
  • Usable for geriatric patients but not for children and adolescents
  • Usable in patients with mild to moderate renal or hepatic impairment
  • Use cautiously in patients with severe renal or hepatic impairment

Interaction

  • Contraindicated with β-adrenergic blockers, anticholinergics, or sympathomimetic agents
  • Caution with hypokalemic treatment

Contraindications

  • Hypersensitivity to Glycopyrronium or Indacaterol or any other component
  • Severe hypersensitivity to milk proteins
  • Contraindicated in patients with asthma without long-term asthma control medication

Side Effects

  • Cardiovascular effects, ocular disorders, urinary retention
  • Gastrointestinal disorders, dry mouth, cough
  • Immediate hypersensitivity reactions, cardiovascular effects, hypokalemia
  • Headache, nervousness, insomnia, muscle spasms, fatigue, malaise, tremor
  • Common adverse drug reactions include cough and oropharyngeal pain

Pregnancy & Lactation

  • Pregnancy category C
  • Use during pregnancy only if expected benefit justifies potential risk to the fetus
  • Consideration for use during lactation only if expected benefit to the woman is greater than any possible risk to the infant

Precautions & Warnings

  • Increased risk of serious asthma-related events with LABA monotherapy
  • Do not initiate in acutely deteriorating COPD or asthma
  • Use with caution in patients with cardiovascular disorders, convulsive disorders, diabetes mellitus, and thyrotoxicosis
  • Worsening of narrow-angle glaucoma and urinary retention may occur
  • Be alert to hypokalemia and hyperglycemia

Overdose Effects

  • No information on clinically relevant overdosing with the product
  • Supportive and symptomatic treatment indicated for overdose effects
  • Hospitalization recommended for serious cases

Therapeutic Class

  • Combined bronchodilators

Storage Conditions

  • Avoid storage in direct sunlight or heat
  • Store in a cool & dry place
  • Keep away from eyes
  • Keep all medicines out of reach of children

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