Progil 200 mg/5 ml (Powder for Suspension)
40 ml bottle: ৳ 1,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Aci limited |
| Also available as |
Title and Categories
- Progil - Azole Antifungal Medicine
- Therapeutic Class: Other Antifungal Preparations
Indications
- Indicated for use in patients 12 years of age and older
- Treatment of invasive aspergillosis
- Treatment of candidemia
- Treatment of disseminated candidiasis in specific areas
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by certain fungal species
- For patients intolerant of, or refractory to other therapy
Pharmacology
- Voriconazole is a triazole antifungal medication
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral tablet and powder for suspension available
- Take at least one hour before or after a meal
- Different loading and maintenance dose regimens based on body weight
- Intravenous dosage for different infections
Interactions
- Adjust dosage and monitor for adverse reactions with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Potential to increase concentrations and activity of certain drugs
- Increase maintenance dosage with co-administration of specific drugs
Contraindications
- Known hypersensitivity to Voriconazole or any other components
- Co-administration with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies potential risk to the fetus
Precautions & Warnings
- Careful assessment of benefit-risk balance for long-term exposure
- Reports of squamous cell carcinoma of the skin (SCC) with long-term Progil treatment
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No data available for Progil overdose
Reconstitution
- Instructions provided for reconstitution of suspension
- Shake the bottle well before adding water
- Discard suspension 14 days after reconstitution
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C and protected from light
- Store Progil powder for suspension between 2°C to 8°C