Sasolin D 0.4 mg+0.5 mg (Capsule)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride dutasteride |
| Company | Aci limited |
Indications
- Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH)
- Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH
Pharmacology
- Combination of Tamsulosin Hydrochloride and Dutasteride
- Improvement in urine flow rate
- Reduction in symptoms of BPH
- Tamsulosin affects the dynamic component of BPH
- Dutasteride affects the static component of BPH
- Dutasteride inhibits conversion of Testosterone to Dihydrotestosterone (DHT)
Dosage & Administration
- Oral administration
- Recommended dose for adults (including elderly): one capsule daily
- No dosage adjustment for renal impairment
- Caution in patients with mild to moderate hepatic impairment
- Contraindicated in severe hepatic impairment
Interaction
- No formal drug interaction studies for the combination
- Metabolism of Dutasteride by CYP3A4 and CYP3A5
- Potential interaction with potent CYP3A4 inhibitors
- No effect on the pharmacokinetics of Tamsulosin or terazosin
- Caution with concomitant administration of certain drugs
Contraindications
- Contra-indicated in women, children, and adolescents
- Hypersensitivity to Dutasteride or Tamsulosin, soya, peanut, or any excipients
- History of orthostatic hypotension
- Severe hepatic impairment
Side Effects
- Common adverse reactions: impotence, decreased libido, breast disorders, ejaculation disorders, dizziness
Pregnancy & Lactation
- Contra-indicated for use by women
- Effect on male fertility
- Requirement to avoid exposure of partner to semen
- No information on excretion in human milk
Precautions & Warnings
- Careful benefit-risk assessment
- Increased risk of adverse events including cardiac failure
- Effects on prostate-specific antigen (PSA) and prostate cancer detection
- Evaluation for prostate cancer risk
- Caution in renal impairment
- Potential hypotension
- Intraoperative Floppy Iris Syndrome
- Avoid contact with leaking capsules
- Caution in hepatic impairment
- Reporting of changes in breast tissue
Overdose Effects
- No data available for the combination
- No specific antidote for Dutasteride
- Reported acute Tamsulosin overdose and management
Therapeutic Class
- BPH/Urinary retention/Urinary incontinence
Storage Conditions
- Cool and dry place, protected from light