Selium 5 mg (Tablet)
Unit Price: ৳ 0.69 (10 x 10: ৳ 69.00)
Strip Price: ৳ 6.90
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Silco pharmaceutical ltd |
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
Pharmacology
- Attaches to GABA receptor
- Potentiates the effect of GABA
- Rapid absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through bile into intestine
- Eliminated with the feces
- Significant absorption after rectal administration
Dosage & Administration
- Oral administration for anxiety and associated insomnia
- IM/slow IV injection for severe acute anxiety and febrile convulsion in children
- Rectal administration for children
Interaction
- Not recommended with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Increased clearance by phonobarbitone
- Decreased clearance by cimetidine
- Inhibition of metabolism by omeprazole and isoniazid
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Avoid prolonged use
- Avoid abrupt withdrawal
- Use with caution in respiratory disease
- Use with caution in muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Rarely coma and death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store below 25˚C temperature
- Store in a dry place
- Protect from light